| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9624 | Sparteine sulfate pentahydrate Featured | (-)-Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. |
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| DC11984 | AMG 8379 | A potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM. |
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| DC11490 | A-317567 | A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
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| DC2061 | A-803467 Featured | A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
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| DC11289 | AM-0466 Featured | AM-0466 is a potent and selective NaV1.7 Inhibitor (Nav 1.7 IC50 = 21 nM; Nav 1.5 IC50 =>30.0 uM. PXR = 22% @10 uM; CYP 2C9 IC50 = 4.6 uM; CYP3A4 TDI IC50 =>50.0 uM.). |
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| DC9909 | AM2099 Featured | AM-2099 is a potent and selective NaV1.7 Inhibitor. |
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| DC11649 | Jamaicin (AnCoA4) Featured | AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM. |
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| DC9193 | Carbamazepine Featured | Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. |
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| DC7990 | Cariporide | Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). |
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| DC8095 | Raxatrigine hydrochloride Featured | CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. |
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| DC9623 | Flecainide (acetate) Featured | Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. |
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| DC10907 | GNE-131 Featured | GNE-131 is a novel NaV1.7 inhibitor with IC50 0.003uM,improving metabolic stability,efficacy in mouse IEM model at C-plasma <2.8uM. |
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| DC8006 | GS967(GS-458967) Featured | GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa). |
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| DC8213 | ICA-121431 Featured | ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels. |
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| DC8124 | ETH 2120(Sodium ionophore III) Featured | Ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode. |
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| DC8797 | Lacosamide Featured | Lacosamide (Vimpat; Erlosamide) is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. |
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| DC8974 | Mexiletine Hydrochloride Featured | Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound. |
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| DC8666 | Nav1.7-IN-2 | Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. |
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| DC9796 | Nicainoprolhe(Nicainoprol) Featured | Nicainoprolhe is an antiarrhythmic agent,a fast-sodiumchannel blocking drug (class Ib), also protected isolated rat hearts against reperfusion arrhythmias. |
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| DC9001 | Oxcarbazepine | Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. |
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| DC10529 | PF 05089771 Featured | PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM. |
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| DC10038 | PF-01247324 Featured | PF-01247324 is an orally bioavailable, selective and potent NaV1.8 channel blocker that inhibits that exhibits analgesic efficacy in rodent behavioral models of pain. |
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| DC12334 | PF-05241328 | PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM. |
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| DC10834 | PF-06869206 Featured | PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). |
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| DC9024 | Phenytoin sodium | Phenytoin sodium is an inactive voltage-gated sodium channel stabilizer. |
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| DCAPI1588 | Pilsicainide hydrochloride | Pilsicainide hydrochloride is a selective Na+ channel blocker (IC30 values are 9 and 60 μM for inward Na+ and Ca2+ currents respectively). Shows antiarrhythmic effects in vivo. Orally active. |
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| DC10224 | Procaine | Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. |
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| DC9162 | Ranolazine HCl Featured | Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). |
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| DC7287 | Ralfinamide Featured | Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain. |
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| DC7505 | Sodium-Channel-inhibitor-1 | Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. |
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