| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC12277 | (-)-BAY-1251152 Featured | (-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. |
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| DCZ-158 | CALCIUML-5-METHYLTETRAHYDROFOLATE | >98%,Standard References |
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| DCK-004 | corilagin | >98%,Standard References |
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| DC8567 | 3-(4-Pyridyl) Featured | 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay |
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| DCAPI1525 | 5-Azacytidine Featured | 5-Azacytidine is a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (Dnmt), forming covalent adducts with cellular DNMT1 depleting enzyme activity. 5-Azacytidine also improves t |
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| DC8944 | 5-Fluorouracil | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
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| DC11873 | CDK12 inhibitor E9 R-isomer | A clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
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| DC11874 | CDK12 inhibitor E9 racemate | A clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
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| DC11932 | GPX-150 | A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
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| DC11779 | TNKS-IN-41 | A highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively. |
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| DC11718 | Debromohymenialdisine | A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively. |
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| DC11851 | Clitocine | A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent. |
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| DC11863 | CA224 | A non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM. |
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| DC11888 | Arfolitixorin | A novel antifolate modulator compound.. |
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| DC11953 | MU 380 | A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2. |
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| DC11799 | G1T38 | A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
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| DC11800 | G1T38 dihydrochloride | A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
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| DC11715 | PV-1115 | A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM. |
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| DC11654 | VRX-0466617 | A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM. |
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| DC11672 | G-9791 | A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively. |
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| DC11643 | Olomoucine Featured | A potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase. |
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| DC11714 | PV-1019 | A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM. |
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| DC11717 | PD-321852 | A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM. |
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| DC11710 | GDC-0425 | A potent, selective and orally active Chk1 inhibitor. |
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| DC11706 | R-10015 Featured | A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM . |
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| DC11635 | Poloxin-2 | A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM. |
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| DC11711 | VER-158411 | A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively. |
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| DC11733 | SAR-020106 | A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM. |
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| DC11704 | CFI-401870 | A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM. |
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| DC11677 | CCT-271850 | A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM. |
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