Cell Cycle/DNA Damage

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Cat. No.	Product Name	Field of Application
DC12277	(-)-BAY-1251152 Featured	(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.
DCZ-158	CALCIUML-5-METHYLTETRAHYDROFOLATE	>98%,Standard References
DCK-004	corilagin	>98%,Standard References
DC8567	3-(4-Pyridyl) Featured	3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay
DCAPI1525	5-Azacytidine Featured	5-Azacytidine is a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (Dnmt), forming covalent adducts with cellular DNMT1 depleting enzyme activity. 5-Azacytidine also improves t
DC8944	5-Fluorouracil	5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
DC11873	CDK12 inhibitor E9 R-isomer	A clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux.
DC11874	CDK12 inhibitor E9 racemate	A clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux.
DC11932	GPX-150	A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM.
DC11779	TNKS-IN-41	A highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.
DC11718	Debromohymenialdisine	A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.
DC11851	Clitocine	A naturally occurring nucleoside analog that possesses antitumor activity, also is a potent and efficacious readthrough agent.
DC11863	CA224	A non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM.
DC11888	Arfolitixorin	A novel antifolate modulator compound..
DC11953	MU 380	A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2.
DC11799	G1T38	A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively.
DC11800	G1T38 dihydrochloride	A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively.
DC11715	PV-1115	A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM.
DC11654	VRX-0466617	A potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM.
DC11672	G-9791	A potent and selective group I PAK (pan-PAK1/2/3) inhibitor with Ki of 0.95/2 nM for PAK1/2, respectively.
DC11643	Olomoucine Featured	A potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase.
DC11714	PV-1019	A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
DC11717	PD-321852	A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
DC11710	GDC-0425	A potent, selective and orally active Chk1 inhibitor.
DC11706	R-10015 Featured	A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM .
DC11635	Poloxin-2	A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM.
DC11711	VER-158411	A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.
DC11733	SAR-020106	A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM.
DC11704	CFI-401870	A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM.
DC11677	CCT-271850	A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM.

Cell Cycle/DNA Damage

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