Home > Inhibitors & Agonists > Nuclear Receptor/Transcription Factor > Farnesoid X Receptor (FXR)
Cat. No. Product name CAS No.
DCE-016 Chenodeoxycholic acid

>98%,Standard References

474-25-9
DC11547 LY-2562175 Featured

A novel potent, selective, partial FXR agonist with EC50 of 193 nM.

1103500-20-4
DC10868 Cilofexor Featured

Cilofexor (GS-9674, GS9674) is novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models.

1418274-28-8
DC8069 Fexaramate Featured

Fexaramate is a potent, selective farnesoid X receptor agonist.

592524-75-9
DC8085 Fexaramine Featured

Fexaramine is a potent, selective FXR activator.

574013-66-4
DC8070 Fexarene Featured

Fexarene is a potent, selective farnesoid X receptor agonist.

574013-68-6
DC8071 Fexarine Featured

Fexarine is a potent, selective farnesoid X receptor agonist.

574013-67-5
DC7566 GW-4064 Featured

GW 4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).

278779-30-9
DC7430 Obeticholic acid (INT-747) Featured

INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity.

459789-99-2
DC10470 SB756050 Featured

SB-756050 is a Farnesoid X receptor (FXR) (NR1H4) agonist.

447410-57-3
DC10737 Tropifexor (LJN452) Featured

Tropifexor (LJN452) is a highly potent non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

1383816-29-2
DC7040 WAY-362450 (XL335; Turofexorate isopropyl) Featured

WAY-362450 (XL335; Turofexorate isopropyl) is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM.WAY-362450 is useful for dyslipidemia.

629664-81-9
DC28475 NR1H4 activator 1

NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease.

2242855-68-9
DC28850 Tauro-Obeticholic acid

Tauro-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

863239-61-6
DC28851 Glyco-Obeticholic acid

Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist.

863239-60-5
DC46688 Sevelamer-(d5)n hydrochloride

Sevelamer-(d5)n hydrochloride is the deuterium labeled Sevelamer hydrochloride. Sevelamer hydrochloride is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin.

DC47987 FXR/TGR5 agonist 1

FXR/TGR5 agonist 1 has agonist action on FXR and TGR5, and can be used for the treatment of fatty liver disease.

2677689-72-2
DC50221 NDB

NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research.

1660153-08-1
DC50222 BMS-986318

BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.

2314378-09-9
DC50223 Chenodeoxycholic acid-d5

Chenodeoxycholic acid-d5 (CDCA-d5) is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

52840-12-7
DC50224 Chenodeoxycholic acid-13C

Chenodeoxycholic acid-13C (CDCA-13C) is the 13C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

52918-92-0
DC70074 GSK-2324

GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.

1020567-30-9
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