Home > Inhibitors & Agonists > Tyrosine Kinase > Focal Adhesion Kinase (FAK)
Cat. No. Product name CAS No.
DC8009 CEP-37440 Featured

CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).

1391712-60-9
DC7695 Defactinib (VS-6063, PF-04554878) Featured

Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel.

1073154-85-4
DC10100 Defactinib hydrochloride Featured

Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel.

1073160-26-5
DC8331 GSK2256098 Featured

GSK2256098 is small molecule FAK kinase inhibitor.

1224887-10-8
DC9787 NAMI-A

NAMI-A is a ruthenium anticancer agent and a metastasis inhibitor.

201653-76-1
DC4106 PF573228 Featured

PF 573228 is a inhibitor of FAK with IC50 of 4 nM.

869288-64-2
DC3168 PF-562271 PHSO3H SALT Featured

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

939791-38-5
DC7941 PF-431396 Featured

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor , PF-431396 has a Kd value of 445 nM for BRD4.

717906-29-1
DC8526 PF4618433 Featured

PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796.

1166393-85-6
DC3169 PF-562271 Featured

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

717907-75-0
DC7241 PND-1186 Featured

PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.

1061353-68-1
DC7885 NVP-TAE226 Featured

TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

761437-28-9
DC8376 TAS-301 Featured

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation.

193620-69-8
DC9446 Y15 Featured

Y15 is a novel small molecule FAK phosphorylation inhibitor; specifically block phosphorylation of Y397-FAK and total phosphorylation of FAK.

4506-66-5
DC40366 Petunidin chloride

Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin that imparts blue-red pigments to flowers, fruits, and red wine. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

1429-30-7
DC42457 PND-1186 hydrochloride

PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis.

1356154-94-3
DC46369 GSK215

GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect.

DC48742 YH-306

YH-306 is a candidate drug in preventing growth and metastasis of colorectal cancer by modulating FAK signalling pathway.

1373764-75-0
DC49068 AMP-945

AMP-945 is an inhibitor of the enzyme focal adhesion kinase (FAK).

1393653-34-3
DC50220 FAK-IN-2

FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC50= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis.

DC70256 BJG-03-025

BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM.BJG-03-025 demonstrates excellent kinome selectivity was profiled by KINOMEscan screening, PLK1 proved to be a false positive with IC50 of 8.3 uM, 100-300-fold selective for FAK.BJG-03-025 displays antiproliferative activity in three-dimensional (3D)-breast and gastric cancer models and impacts cellular signaling and migration.BJG-03-025 decreased phosphorylated FAK (pFAK Y397) in gastric cancer CDH1–/–RHOAY42C/+ organoid model, decreased aberrant signaling and proliferation of gastric cancer organoids.

2553213-90-2
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