Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Indoleamine 2,3-Dioxygenase (IDO)
Cat. No. Product name CAS No.
DC10131 BMS-986205(Linrodostat) Featured

BMS-986205 is an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic activity, alone and in combination with nivolumab in advanced cancers in a phase 1/2a trial

1923833-60-6
DC8389 Epacadostat (INCB024360) Featured

Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2.

1204669-58-8
DC10098 IDO-IN-1 Featured

IDO-IN-1 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM, shows activity in Hela cell (IC50=12 nM).

914638-30-5
DC10421 IDO-IN-2 Featured

IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.

1668565-74-9
DC7015 INCB024360 analogue(IDO-IN-1) Featured

INCB024360 is a potent IDO1 inhibitor(IC50=10 nM) with desirable pharmaceutical properties, which is poised to start clinical trials in cancer patients.

914471-09-3
DC8021 Indoximod (NLG-8189) Featured

NLG-8189 is an inhibitor of IDO and INDOL1 (IDO2)

110117-83-4
DC10022 PF06840003 Featured

PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.

198474-05-4
DC11159 Roxyl-WL

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.

667887-37-8
DC28283 (Rac)-IDO1-IN-5

(Rac)-IDO1-IN-5 (Example 1) is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

2166616-74-4
DC28284 (S)-IDO1-IN-5

(S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

2166616-76-6
DC28673 IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.

2346614-58-0
DC40744 (Rac)-Indoximod

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.

26988-72-7
DC42337 IDO-IN-6

IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.

1402837-76-6
DC42338 IDO-IN-8

IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.

1402837-77-7
DC46155 BMT-297376

BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.

2251031-81-7
DC47596 IDO-IN-15

IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM).

2433886-87-2
DC47597 IDO-IN-14

IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.

2568302-02-1
DC48216 NLG802

NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

2071683-99-1
DC48217 IDO1-IN-11

IDO1-IN-11 is an IDO1 inhibitor with an IC50 value of 0.6 nM.

2306411-34-5
DC48218 IDO1-IN-12

IDO1-IN-12 is a potent and orally available IDO1 inhibitor.

2379570-48-4
DC48664 IDO1/2-IN-1

IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active.

2310286-45-2
DC49739 IDO1-IN-13

IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC50 of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC50= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues.

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