Cat. No. | Product name | CAS No. |
DC11439 |
Nemorexant
Featured
ACT-541468 is a dual orexin receptor antagonist. |
1505484-82-1 |
DC7692 |
Almorexant HCl (Act-078573)
Featured
Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
913358-93-7 |
DC8173 |
Lemborexant(E2006)
Featured
Lemborexant (E-2006) is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia. |
1369764-02-2 |
DC9297 |
MDK-5220(Orexin-2 receptor agonist)
Featured
MDK-5220(Orexin-2 receptor agonist) is the first selective nonpeptidic orexin 2 receptor (OX2R) agonist (OX2R EC50 = 0.023 μM, Emax = 98%; OX1R EC50 = 1.616 μM, Emax = 100%) |
1796565-52-0 |
DC9966 |
MK-1064
Featured
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia. |
1207253-08-4 |
DC7646 |
MK3697
MK-3697 is a third insomnia drug, currently being developed by Merck. MK-3697 is a potent and selective Orexin receptor antagonist with Ki = 0.95 nM. |
1224846-01-8 |
DC7495 |
SB-334867 HCl
Featured
SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
249889-64-3 |
DC8419 |
SB-334867
Featured
SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
792173-99-0 |
DC7277 |
SB-408124
Featured
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. |
288150-92-5 |
DC9573 |
SB-674042
Featured
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. |
483313-22-0 |
DC5017 |
Suvorexant
Featured
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia. |
1030377-33-3 |
DC7513 |
TCS 1102
Featured
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). |
916141-36-1 |
DC11461 |
TCS-OX2-29
Featured
TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1. |
372523-75-6 |
DC28246 |
EMPA
Featured
EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively. |
680590-49-2 |
DC28252 |
Seltorexant hydrochloride
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. |
1293284-49-7 |
DC41022 |
Orexin receptor antagonist 3
Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1. |
1293282-55-9 |
DC41789 |
[Ala11,D-Leu15]-Orexin B(human)
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM). |
532932-99-3 |
DC41790 |
[Ala11,D-Leu15]-Orexin B(human) TFA
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM). |
|
DC41791 |
OXA(17-33)
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ~23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM). |
343268-91-7 |
DC41792 |
OXA(17-33) TFA
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ~23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM). |
|
DC42501 |
Orexin receptor antagonist 2
Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia. |
1457940-75-8 |
DC45872 |
YNT-185 dihydrochloride
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models. |
1804978-82-2 |