Cat. No. | Product name | CAS No. |
DC11932 |
GPX-150
A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
236095-29-7 |
DC8923 |
AS-1413(Amonafide)
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
69408-81-7 |
DC11470 |
Belotecan hydrochloride(CKD-602)
Featured
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative. |
213819-48-8 |
DC7905 |
beta-Lapachone (ARQ-501, CO-501)
Featured
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2. |
4707-32-8 |
DC9832 |
Betulinic acid
Featured
Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M. |
472-15-1 |
DC6701 |
Camptothecine
Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. |
7689-03-4 |
DCAPI1566 |
Cytarabine hydrochloride
Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent which binds to topoisomerase I resulting in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinof |
69-74-9 |
DC4188 |
Doxorubicin hydrochloride
Featured
Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
25316-40-9 |
DC10410 |
Ellipticine hydrochloride
Featured
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. |
5081-48-1 |
DC8325 |
Ellipticine
Featured
Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
519-23-3 |
DC2102 |
Etoposide 4'-Phosphate
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
117091-64-2 |
DC7131 |
GENZ-644282
Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity(IC50=1.2 nM). |
529488-28-6 |
DC8111 |
Idarubicin Hydrochloride
Featured
Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor. |
57852-57-0 |
DC4153 |
Irinotecan hydrochloride trihydrate
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
136572-09-3 |
DC8934 |
Irinotecan
Featured
Irinotecan(CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1. |
97682-44-5 |
DC5905 |
SN-38(NK-012)
Featured
SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
86639-52-3 |
DC8852 |
SW-044248
Featured
SW-044248 is a Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. |
522650-83-5 |
DC8536 |
TAS-103 2HCl
Featured
TAS-103 2Hcl(BMS-247615 2Hcl) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
174634-09-4 |
DC7898 |
TAS-103(BMS247615)
TAS-103(BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
174634-08-3 |
DC7530 |
Voreloxin
Featured
Voreloxin(SNS-595; AG 7352) is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II. |
175414-77-4 |
DC5184 |
Epirubicin HCl (4'-epidoxorubicin)
Featured
Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. |
56390-09-1 |
DC28079 |
RPR121056
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE. |
181467-56-1 |