| DC11932 |
GPX-150 |
A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
|
| DC8923 |
AS-1413(Amonafide) |
Amonafide(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
|
| DC11470 |
Belotecan hydrochloride(CKD-602)
Featured
|
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative. |
|
| DC7905 |
beta-Lapachone (ARQ-501, CO-501)
Featured
|
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2. |
|
| DC9832 |
Betulinic acid
Featured
|
Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M. |
|
| DC6701 |
Camptothecine |
Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. |
|
| DCAPI1566 |
Cytarabine hydrochloride
Featured
|
Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent which binds to topoisomerase I resulting in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinof |
|
| DC4188 |
Doxorubicin hydrochloride
Featured
|
Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
|
| DC10410 |
Ellipticine hydrochloride
Featured
|
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. |
|
| DC8325 |
Ellipticine
Featured
|
Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
|
| DC2102 |
Etoposide 4'-Phosphate |
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
|
| DC7131 |
GENZ-644282 |
Genz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity(IC50=1.2 nM). |
|
| DC8111 |
Idarubicin Hydrochloride
Featured
|
Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor. |
.gif)
|
| DC4153 |
Irinotecan hydrochloride trihydrate |
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
|
| DC8934 |
Irinotecan
Featured
|
Irinotecan(CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1. |
|
| DC5905 |
SN-38(NK-012)
Featured
|
SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
|
| DC8852 |
SW-044248
Featured
|
SW-044248 is a Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. |
|
| DC8536 |
TAS-103 2HCl
Featured
|
TAS-103 2Hcl(BMS-247615 2Hcl) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
|
| DC7898 |
TAS-103(BMS247615) |
TAS-103(BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII). |
|
| DC7530 |
Voreloxin
Featured
|
Voreloxin(SNS-595; AG 7352) is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II. |
|
| DC5184 |
Epirubicin HCl (4'-epidoxorubicin)
Featured
|
Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. |
|
| DC28079 |
RPR121056 |
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE. |
|
| DC28185 |
Chloroquinoxaline sulfonamide |
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity. |
|
| DC40076 |
CH-0793076 |
CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). |
|
| DC40077 |
CH-0793076 TFA |
CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein). |
|
| DC40214 |
Camptothecin-20(S)-O-propionate |
Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor. |
|
| DC40352 |
T-2513 |
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death. |
|
| DC41116 |
Merbarone |
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage. Merbarone is an anticancer agent. |
|
| DC41162 |
Gimatecan |
Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. |
|
| DC42296 |
Exatecan D5 Mesylate |
Exatecan D5 Mesylate (DX8951f-D5) is deuterium labeled Exatecan Mesylate. Exatecan Mesylate is a DNA topoisomerase I, with an IC50 of 0.975 μg/mL. |
|
