| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DCL-027 | Lipoic acid Featured | Lipoic acid is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. Lipoic acid shows a favorable selectivity profile on Nav, Cav, SK, and IK channels. Lipoic acid causes distinct activation from a concentration of 0.3 and 10 µM Lipoic acid left-shifted the voltage activation curve by 60 mV. Lipoic acid reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. |
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| DC11927 | iNUB | A small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM. |
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| DC11926 | NDMC101 Featured | A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
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| DC11925 | ABD328 | ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo. |
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| DC11182 | AM-0216 | AM-0216 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent. |
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| DC11181 | AM-0561 | AM-0561 (AM0561) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 0.3 nM.. |
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| DC11180 | Amgen 16 | Amgen16 is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1.. |
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| DC8658 | AZD3264 | AZD 3264 is an IkB-kinase IKK2 Inhibitor, IKK2 has been identified as one of the novel pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
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| DC7869 | BAY11-7082 Featured | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Also inhibiting components of the ubiquitin system. |
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| DC8038 | Bay 11-7085 Featured | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with an IC50 value of 10 μM. |
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| DC11960 | BI605906 Featured | BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
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| DC8827 | Didox Featured | Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers. |
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| DC10939 | Edasalonexent | Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA). |
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| DC8872 | Iguratimod Featured | Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. |
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| DC7158 | IKK-16 HCl Featured | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
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| DC9485 | IKK-16(free base) Featured | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
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| DC9484 | IKK-2 inhibitor VIII Featured | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. |
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| DC7802 | IKK(epsilon)-IN-1 (IKKE-IN-1) Featured | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. |
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| DC8770 | IMD-0354 Featured | IMD-0354 is a synthetic selective NF-kB inhibitor. |
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| DC10768 | IT 901 Featured | IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. |
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| DC7741 | JSH-23 Featured | JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. |
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| DC8065 | LY2409881 trihydrochloride Featured | LY2409881 is a novel inhibitor of IκB kinase β (IKK2). |
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| DC11066 | MALT1 paracaspase inhibitor 3 | MALT1 paracaspase inhibitor 3 is a potent, specific, covalent inhibitor of MALT1 paracaspase with Ki of 10 nM, exhibits 10-and 100-fold improved potency in vitro and in vivo compared with Z-VRPR-fmk. |
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| DC9503 | MI 2 (MALT1 inhibitor) Featured | MI 2(MALT1 inhibitor) is a small molecule and irreversible inhibitor of MALT1 with IC50 of 5.84 uM(suppression of proliferation in ABCDLBCL). |
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| DC7621 | MI 2 (Menin-MLL Inhibitor) Featured | MI-2 is an inhibitor of MALT1 with IC50 value of 5.84 μM. |
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| DC10927 | NIK inhibitor 4f(NIK SMI1) Featured | NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice. |
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| DC7969 | PS-1145 Featured | PS-1145 has been shown to be an IKK (IKB kinase) inhibitor. |
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| DC10636 | SC75741 Featured | SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. |
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| DC10661 | Takinib Featured | Takinib is a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. |
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| DC7159 | TPCA-1 Featured | TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays>22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. |
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