| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10616 | 3-TYP Featured | 3-TYP is a selective SIRT3 inhibitor. |
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| DC11585 | MZ-242 | A novel potent, selective Sirt2 inhibitor with IC50 of 0.118 uM. |
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| DC11587 | SirReal1 Featured | A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM. |
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| DC8437 | AGK2 Featured | AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. |
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| DC7540 | SIRT2 Inhibitor II, AK-7 Featured | AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). |
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| DC10744 | Cambinol Featured | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. |
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| DC10579 | CAY 10602 Featured | CAY10602 is a SIRT1 activator. |
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| DC11213 | E1231 Featured | E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). |
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| DC10658 | OSS-128167(SIRT6-IN-1) Featured | OSS-128167 is a novel SIRT6 inhibitor. |
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| DC10002 | Salermide Featured | Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1. |
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| DC8867 | SirReal2 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
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| DC7539 | SIRT2 Inhibitor II, AK-1 Featured | SIRT2 Inhibitor II, AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. |
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| DC12109 | SIRT5 inhibitor | SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. |
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| DC8900 | SRT1720 Featured | SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM). |
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| DC7300 | SRT1720 HCl Featured | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3. |
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| DC8412 | SRT2104 Featured | SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. |
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| DC11156 | SRTCX1002 | SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay. |
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| DC11157 | SRTCX1003 | SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay. |
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| DC1065 | Tenovin-1 Featured | Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
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| DC7315 | Tenovin-6 Featured | Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator. |
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| DC10076 | Thiomyristoyl Featured | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. |
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| DC7127 | EX-527(Selisistat) Featured | EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3. |
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| DC7428 | Inauhzin Featured | Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). |
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| DC29239 | MC3482 (MC 3482) | MC3482 is a potent, specific SIRT5 inhibitor, increases the ammonia content in cells leading to autophagy and mitophagy, shows selective SIRT5 inhibition vs SIRT1-3. |
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| DC40312 | Nicotinamide riboside tartrate | Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease. |
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| DC40313 | Nicotinamide riboside malate | Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease. |
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| DC40750 | SIRT-IN-3 | SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively). |
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| DC40782 | SIRT7 inhibitor 97491 Featured | SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.. |
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| DC40849 | SIRT1-IN-1 Featured | SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity. |
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| DC45270 | CHIC35 | CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research. |
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