| DC11811 |
SCY-078 |
A novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml). |
|
| DC11527 |
Quilseconazole
Featured
|
A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor. |
|
| DC11752 |
iKIX1 |
A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM. |
|
| DC7061 |
AN-2690(Tavaborole) |
AN-2690(Tavaborole), an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis. |
|
| DC11088 |
Fosmanogepix |
antifungal. |
|
| DCAPI1497 |
Cancidas
Featured
|
Caspofungin is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acts by inhibition of the synthesis of β (1,3)-D-glucan, an e |
|
| DC7824 |
Fosfluconazole(INN) |
Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole |
|
| DCAPI1366 |
Itraconazole (Sporanox) |
Itraconazole (Sporanox) |
|
| DCAPI1447 |
Pneumocandin B0
Featured
|
Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from several species of several different genera, notably Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β |
|
| DCAPI1093 |
Posaconazole
Featured
|
Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. |
|
| DCAPI1383 |
Terbinafine (Lamisil, Terbinex) |
Terbinafine (Lamisil, Terbinex) |
|
| DCAPI1344 |
Terbinafine HCl
Featured
|
Terbinafine also known under the trade name Lamisil. It is highly hydrophobic and tends to accumulate in hair, skin, nails, and fatty tissue. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. |
|
| DCAPI1451 |
Voriconazole
Featured
|
Voriconazole is an ergosterol biosynthesis inhibitor, as well as systemic antifungal. This compound, like many antifungal agents, is an inhibitor of CYP2C9, an enzyme involved in the oxidative metabolism of many xenobiotics. |
|
| DC28220 |
Rezafungin
Featured
|
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp.. |
|
| DC28221 |
Rezafungin acetate |
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp.. |
|
| DC28240 |
Alexidine dihydrochloride
Featured
|
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. |
|
| DC28695 |
5-Aminouridine |
5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses. |
|
| DC28801 |
SSF-109 |
SSF-109 is a broad-spectrum fungicide which has protective activity against plant disease. SSF-109 inhibits the biosynthesis of ergosterol at the 14α-demethylation step in Botrytis cinerea. |
|
| DC28993 |
Posaconazole-D4 |
Posaconazole-D4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. |
|
| DC28997 |
(S,S)-Valifenalate |
(S,S)-Valifenalate ((S,S)-IR5885) is an acylamino acid fungicide and is used to control a wide range of fungi belonging to the class of Oomycetes. (S,S)-Valifenalate ((S,S)-IR5885) interferes with the cell-wall synthesis thus affecting the growth stages of the pathogens controlled, both outside (on the spores) or inside the plant (on the mycelium). |
|
| DC29068 |
Thymol iodide |
Thymol iodide is a compound of Iodide and Thymol. Thymol iodide acts as a substitute for iodoform. Thymol iodide is an iodine derivative of Thymol (a phenol derived from thyme oil), which is mostly used as mild antiseptic and fungicide. |
|
| DC40231 |
Cyprodinil |
Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s=0.44, 4.8, and 0.03 μM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC50=1.91 μM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC50=15.1 μM). |
|
| DC40264 |
Lipoxamycin |
Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM. |
|
| DC40265 |
Lipoxamycin hemisulfate
Featured
|
Lipoxamycin hemisulfate is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM. |
|
| DC40346 |
Kresoxim-methyl |
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme. |
|
| DC40363 |
Sordarin sodium |
Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C.?albicans,?C.?glabrata, and?C.?neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae). |
|
| DC40404 |
Isoeleutherin |
Isoeleutherin is a naphthopyran derivative isolated from E. americana Merr. Et Heyne with anti-fungal, anti-viral, and anti-tumor activities. Isoeleutherin plays an important role in selective modulation of T helper cell-mediated immune responses. |
|
| DC40453 |
Tolytoxin |
Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells. |
|
| DC40668 |
8-Abietenic acid |
8-Abietenic acid is the secondary metabolite of mucorinic acid and is isolated from a solid culture of the fungus Mucor spp. isolated on insect Acalymma bivittula. 8-Abietenic acid exhibits antibacterial and insecticidal activities. |
|
| DC40695 |
2,2-Dibromopropanoic acid |
2,2-Dibromopropanoic acid is a dibromo product based on panoic acid. Propionic acid is a short chain fatty acid and acts as chemical intermediate. Propionic acid is also a mold inhibitor and widely used in food preservative. |
|
