| DC11849 |
DSM421 |
A potent, selective P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 53 nM. |
|
| DC11738 |
SCYX-7158 |
An orally-active, CNS permeable benzoxaborole antiprotozoal agent. |
|
| DC11409 |
DSM265
Featured
|
DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM. |
|
| DC10301 |
Emodepside
Featured
|
Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. |
|
| DC10258 |
Mebendazole |
Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking g |
|
| DC7791 |
NITD 609 |
NITD 609 is a novel and potent drug
candidate for the treatment of
uncomplicated malaria |
|
| DCAPI1553 |
Pyrimethamine |
Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(Pgp) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux |
|
| DC8930 |
Rafoxanide |
Rafoxanide is a salicylanilide used as an antiparasitic agent. |
|
| DC8336 |
Tizoxanide
Featured
|
Tizoxanide is a potent inhibitor of hepatitis B virus and hepatitis C virus. |
|
