| DC12367 |
Cyclic guanosine monophosphate-adenosine monophosphate
Featured
|
2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA. |
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| DC11641 |
Cridanimod
Featured
|
A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
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| DC11642 |
Cridanimod sodium
Featured
|
Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
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| DC12321 |
STING agonist-1 trihydrochloride
Featured
|
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist. |
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| DC7404 |
DMXAA
Featured
|
DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3. |
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| DC10876 |
H-151
Featured
|
H-151(H151) is a novel STING (stimulator of interferon genes) antagonist. |
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| DC10908 |
ML RR-S2 CDA
Featured
|
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). |
|
| DC11072 |
SINCRO |
SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes. |
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| DC26063 |
STING Agonist C11
Featured
|
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway. |
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| DC12505 |
STING agonist-4
Featured
|
STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation. |
|
| DC11451 |
STING agonist compound 1
Featured
|
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
|
| DC11179 |
STING CDN agonist IFM Therapeutics |
STING CDN agonist IFM Therapeutics is a synthetic cyclic dinucleotide (CDN) agonist of STING, stimulates potent immunity against cancer.. |
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| DC10960 |
STING inhibitor C-176
Featured
|
STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING |
|
| DC10959 |
STING inhibitor C-178
Featured
|
STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING). |
|
| DC22331 |
STING agonist compound 3
Featured
|
STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
|
| DC28012 |
c-Di-AMP(Cyclic-Di-AMP) ammonium salt
Featured
|
Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation.
Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2].
Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3].
Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5]. |
|
| DC28013 |
Cyclic-di-GMP(c-di-GMP)
Featured
|
Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system. |
|
| DC39030 |
SR-717
Featured
|
SR-717 is a non-nucleotide, small-molecule STING agonist and functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING.SR-717 functions as a direct cyclic guanosine mo |
|
| DC39031 |
MSA-2
Featured
|
MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2. |
|
| DC39210 |
MSA-2 analogue
Featured
|
MSA-2 analogue is an orally available human STING agonist. |
|
| DC39220 |
STING agonist compound 17
Featured
|
STING agonist compound 17 is a selective stimulator of interferon genes (STING) receptor agonist. |
|
| DC40090 |
Cyclic-di-GMP sodium |
Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species. |
|
| DC40210 |
STING ligand-1 |
STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING. |
|
| DC44158 |
IACS-8803 disodium |
IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy. |
|
| DC60033 |
STING INHIBITOR-2
Featured
|
STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. |
|
| DC60034 |
STING inhibitor-1
Featured
|
STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. |
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|
| DC45896 |
E7766 diammonium salt |
E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities. |
|
| DC46412 |
STING agonist-3 trihydrochloride |
STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
|
| DC46506 |
E7766 disodium |
E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities. |
|
| DC47077 |
Ulevostinag |
Ulevostinag (MK-1454) is a STING agonist. |
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