| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11605 | ONO-0300302 | A novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM. |
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| DC11560 | SPM-242 | A potent, selective S1P3 antagonist with Ki of 0.25 nM. |
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| DC11561 | SPM-242 racemate | A potent, selective S1P3 antagonist with Ki of 0.25 nM. |
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| DC11525 | Mocravimod | A synthetic immunosuppressant that functions as a S1P1 receptor agonist. |
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| DC11754 | AD 2900 Featured | AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively. |
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| DC8621 | AM095 Featured | AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
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| DC8622 | AM095 free acid Featured | AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. |
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| DC8623 | AM966 Featured | AM966 is a high affinity, selective, oral LPA1 (lysophosphatidic acid receptor, IC50=17 nM) antagonist, with selectivity for this receptor over the other LPA receptors. |
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| DC10459 | BMS-986020 Featured | BMS-986020 is an LPA1 antagonist. |
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| DC10924 | BMS986202 Featured | BMS-986202 is a clinical Tyk2 inhibitor that binds to Tyk2 JH2 with IC50 of 0.19 nM and shows remarkably selectivity over other kinases including Jak family members. |
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| DC10357 | Cenerimod | Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. |
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| DC8088 | CYM5442 Featured | CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. |
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| DC10040 | Etrasimod(APD334) Featured | Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1(S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. |
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| DC8936 | Fingolimod | Fingolimod(FTY720 free base) is a S1P antagonist with IC50 of 0.033 nM. |
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| DC8889 | Ki16198 Featured | Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6. |
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| DC7179 | Ki16425 Featured | Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. |
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| DC10630 | ONO-7300243 Featured | ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. |
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| DC8281 | Ozanimod (RPC1063) Featured | Ozanimod (RPC1063) is a selective S1P1R modulator |
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| DC9742 | Ponesimod Featured | Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. |
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| DC10392 | S1p receptor agonist 1 | S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2. |
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| DC10925 | SAR-100842 Featured | SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
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| DC7295 | SphK-I2 Featured | SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
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| DC10923 | TAK-615 Featured | TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays.. |
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| DC10079 | CYM5541 Featured | CYM5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). |
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| DC12355 | Ceralifimod (ONO-4641) | Ceralifimod is selective, high potent agonist for sphingosine 1-phosphate receptors 1 and 5, with EC50s of 27.3, 334 pM for human S1P receptor 1 and 5, respectively. |
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| DC7694 | BAF312 (Siponimod) Featured | BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively |
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| DC10561 | GSK-2018682 Featured | GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis. |
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| DC28232 | CYM50260 | CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
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| DC28233 | CYM 50308 Featured | CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM. |
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| DC28324 | LPA2 antagonist 2 | LPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM, which is ＞480-fold more selective than LPA3 (IC50 of 13.85 μM). |
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