| DC11630 |
ND-378 |
A potent, selective MMP-2 inhibitor with Ki of 230 nM. |
|
| DC11447 |
Astragaloside IV
Featured
|
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. |
|
| DC8133 |
Batimastat(BB-94)
Featured
|
Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133. |
|
| DC9510 |
CTS-1027 |
CTS-1027 is a potent small molecule inhibitor of MMPs(IC50=0.4 nM/0.6 nM for MMP2/MMP13); >1,000 fold selectivity over MMP1.
|
|
| DC11337 |
MMP Substrate II Control |
Dnp-GPLG is a peptide for use as a negative control for activity of matrix metalloproteinases (MMPs) that cleave peptides containing the sequence Dnp-GPLG. |
|
| DC11342 |
MMP-1 Fluorogenic Substrate III |
Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. |
|
| DC11348 |
MMP-1/MMP-9 Fluorogenic Substrate
Featured
|
Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9 |
|
| DC11351 |
MMP-1 Fluorogenic Substrate I
Featured
|
Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8. |
|
| DC11339 |
MMP-8/MMP-26 Fluorogenic Substrate
Featured
|
Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26.The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitro |
|
| DC11347 |
MMP-1 Substrate II
Featured
|
Dnp-PLG-Cys(Me)-HA-DArg-NH2 is a peptide substrate for matrix metalloproteinase-1 (MMP-1).It has an improved kcat/Km ratio compared with the MMP-1 flurogenic substrate Dnp-PLGLWA-DArg-NH2. |
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|
| DC11344 |
MMP-2/MMP-9 Fluorogenic Substrate I |
Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9.The activity of MMP-2 and MMP-9 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitroph |
|
| DC11345 |
MMP-7 Fluorogenic Substrate |
Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7).The activity of MMP-7 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group. |
|
| DC10883 |
GI254023X
Featured
|
GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively. |
|
| DC7135 |
GM6001 (galardin, ilomastat)
Featured
|
GM6001 (galardin, ilomastat) is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4-27 nM. |
|
| DC11404 |
JNJ0966
Featured
|
JNJ0966 is a highly selective compound
that inhibited activation of MMP-9 zymogen and subsequent
generation of catalytically active enzyme. |
|
| DC12108 |
KP-457
Featured
|
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and 5050s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MM |
|
| DC12117 |
Luteolin 7-O-glucuronide (Luteolin 7-glucuronide4)
Featured
|
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
|
| DC8031 |
Marimastat |
Marimastat is a broad spectrum MMP inhibitor and selective TACE inhibitor |
|
| DC11338 |
MMP-2/MMP-7 Fluorogenic Substrate Control
Featured
|
Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. |
|
| DC11368 |
MMP-2/MMP-9 Inhibitor II |
MMP-2/MMP-9 inhibitor II is a dual inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 17 and 30 nM, respectively). |
|
| DC11343 |
MMP-2/MMP-9 Inhibitor III |
MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 10-20 μM for both). |
|
| DC11355 |
MMP-3 Inhibitor
Featured
|
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM. |
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|
| DC7215 |
NSC 405020
Featured
|
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. |
|
| DC7670 |
SB-3CT
Featured
|
SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. |
|
| DC10713 |
S-methyl-KE-298
Featured
|
S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
|
| DC7769 |
Tanomastat |
Tanomastat is an angiogenesis and Matrix Metalloproteinase inhibitor |
|
| DC8131 |
TAPI-2 (TNF Protease Inhibitor 2)
Featured
|
TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively. |
|
| DC28161 |
ARP-100
Featured
|
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM). |
|
| DC28205 |
UK-370106 |
UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50 of 320 nM) and has little effect on keratinocyte migration in vitro. |
|
| DC28288 |
XL-784 free base |
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively. |
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