| DC10625 |
(+)-Bicuculline
Featured
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(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
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| DC9450 |
(R)-Baclofen |
(R)-Baclofen(STX209) is a selective GABAB receptor agonist. |
|
| DC9026 |
Afloqualone |
Afloqualone is a agonist of GABA receptor . |
|
| DC9764 |
Afoxolaner
Featured
|
Afoxolaner is an isoxazoline that inhibits insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), blocking pre and post synaptic transfer of chloride ions across cell membranes. |
|
| DC10311 |
Allopregnanolone
Featured
|
Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor. |
|
| DC11657 |
PPT(Propyl pyrazole triol )
Featured
|
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). |
|
| DC8971 |
Baclofen |
Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. |
|
| DC9935 |
Basmisanil(RG1662)
Featured
|
Basmisanil is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. |
|
| DC10843 |
CGP 52432
Featured
|
CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM). |
|
| DC12100 |
Cirsimaritin |
Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities. |
|
| DC7009 |
CNS-7056 |
CNS 7056 is a new short-acting sedative/anaesthetic that acts on GABAA receptors in the brain. |
|
| DC8706 |
Emamectin Benzoate |
Emamectin Benzoate works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods. |
|
| DC8821 |
Etifoxine Hydrochloride
Featured
|
Etifoxine Hydrochloride is a psychotropic agent with anxiolytic and anticonvulsant activity. Etifoxine Hydrochloride is an activator of GABAA R β2 and GABAA R β3. |
|
| DC11309 |
Fipronil |
Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 and 1,600 nM for cockroach and rat receptors, respectively). |
|
| DC9451 |
Flumazenil |
Flumazenil(Ro 15-1788) is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. |
|
| DC10158 |
Fluralaner
Featured
|
Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels. |
|
| DC9381 |
Gabapentin (hydrochloride) |
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. |
|
| DC8954 |
Gabapentin
Featured
|
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain. |
|
| DC11090 |
GR3027
Featured
|
GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC. |
|
| DC11118 |
HZ-166 |
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors. |
|
| DC4137 |
Indiplon
Featured
|
Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. |
|
| DC10853 |
LAU159
Featured
|
LAU159 is a novelα6β3γ2 GABAA receptor inhibitor. |
|
| DC8642 |
Lorediplon
Featured
|
Lorediplon is a new GABAA modulator Drug for treatment of insomnia. |
|
| DCAPI1574 |
Nefiracetam |
Nefiracetam is a nootropic of the racetam family. Nefiracetam is cognitive enhancer with an IC50 of approximately 150–200 μM for Ro 5-4864. This compound activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Nefiracetam di |
|
| DC8083 |
NS11394
Featured
|
NS11394 possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors. |
|
| DC11267 |
ONO-8590580
Featured
|
ONO-8590580 is a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. |
|
| DC10292 |
Pagoclone |
Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders. |
|
| DC10113 |
Pipequaline
Featured
|
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity. |
|
| DCAPI1330 |
Piracetam |
Piracetam is a cyclic derivative of the neurotransmitter ã-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders. |
|
| DC10578 |
rac BHFF
Featured
|
Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo. |
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