Home > Research Areas > Cardiovascular Disease > Thrombosis
Cat. No. Product name CAS No.
DC5114 Apixaban (BMS 562247-01) Featured

Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

503612-47-3
DC8004 AZD6482 Featured

AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.

1173900-33-8
DC7373 Betrixaban Featured

Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a).

330942-05-7
DCAPI1112 BIBR 953(Dabigatran) Featured

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate.

211914-51-1
DC1010 BIBR-1048 (Dabigatran etexilate) Featured

BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors.

211915-06-9
DC11923 BMS-986120

BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.

1478712-37-6
DC7005 Cangrelor free acid Featured

Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggrega

163706-06-7
DC3147 Clopidogrel hydrogensulfate

Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent.

120202-66-6
DCAPI1417 Clopidogrel

Clopidogrel is an irreversible inhibitor of the P2Y12 receptor, which is responsible for initiating signal transduction via a GPCR. The signal cascade initiates platelet aggregation and thus clopidogrel has the effect of “thinning” the blood.

113665-84-2
DC8913 Dabigatran etexilate mesylate Featured

Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.

872728-81-9
DC8533 E5555 hydrobromide

E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031 μM respectively.

474550-69-1
DC8305 Edoxaban Featured

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention

480449-71-6
DC8793 Edoxaban tosylate monohydrate Featured

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention

1229194-11-9
DC7772 Elinogrel

Elinogrel is a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events.

936500-94-6
DC9443 Otamixaban

Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.

193153-04-7
DC10500 PF-06282999 Featured

PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.

1435467-37-0
DC5108 BAY 59-7939 (Rivaroxaban) Featured

Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.

366789-02-8
DC1101 Ticagrelor (Brilinta,AZD6140) Featured

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.

274693-27-5
DC9489 Tirofiban (hydrochloride monohydrate) Featured

Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist

150915-40-5
DC7327 Tirofiban(L700462;MK383) Featured

Tirofiban(L700462;MK383) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.

144494-65-5
DC8860 Vorapaxar Featured

Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

618385-01-6
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