| DC8086 |
Moclobemide
Featured
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Moclobemide belongs to a new generation of short-acting, reversible, monoamine oxidase (MAO) inhibitors. |
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| DCAP008 |
QS-21
Featured
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QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. |
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| DC7524 |
Uramustine
Featured
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Uramustine (INN), also known as uracil mustard, is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.For the detailed information of Uramustine, the solubility of Uramustine in water, the solubility of Uramustine in DMSO, the solubility of Uramustine in PBS buffer, the animal experiment (test) of Uramustine, the cell expriment (test) of Uramustine, the in vivo, in vitro and clinical trial test of Uramustine, the EC50, IC50,and Affinity of Uramustine, Please contact DC Chemicals.. |
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| DC11019 |
ASP3662
Featured
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ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
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| DC11206 |
HSD-016
Featured
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HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively. |
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| DC11207 |
INCB13739
Featured
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INCB13739 (INCB-13739) is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors.. |
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| DC11205 |
INU-101
Featured
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INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively. |
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| DC20787 |
(-) BI97D6
Featured
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(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively. |
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| DC12277 |
(-)-BAY-1251152
Featured
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(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. |
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| DC7818 |
(-)Blebbistatin
Featured
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(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. |
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| DC20288 |
(-)-CXL017
Featured
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(-)-CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 13.5 uM. |
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| DC22303 |
(-)-Eburnamonine
Featured
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(-)-Eburnamonine is a vasodilator that also acts as a cerebral metabolic stimulant. |
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| DC7961 |
(-)MK-801 maleate
Featured
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(-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . |
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| DC9624 |
Sparteine sulfate pentahydrate
Featured
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(-)-Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. |
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| DC10625 |
(+)-Bicuculline
Featured
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(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
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| DC10656 |
(+)-JQ1 carboxylic acid
Featured
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(+)-JQ1 carboxylic acid is the carboxylic acid form of (+)-JQ1 for derivative synthesis. |
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| DC5019 |
(+)-JQ1
Featured
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(+)-JQ1 is a BET bromodomain inhibitor, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. |
-JQ-1.gif)
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| DC12021 |
(+)-JQ1 PA
Featured
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(+)-JQ1 PA is a Click-activated (alkyne) version of the BET bromodomain inhibitor (+)-JQ1. |
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| DC20149 |
(+)-Kavain
Featured
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(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABA |
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| DC11321 |
(+)-Muscarine (chloride) |
(+)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria. |
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| DC5060 |
(+)PD 128907 |
(+)PD 128907 is a potent D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes. |
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| DC20138 |
(+)-Penbutolol
Featured
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(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action. |
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| DC22282 |
Praeruptorin A
Featured
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(+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum. |
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| DCAPI1411 |
Bisoprolol Fumarate
Featured
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(±)-Bisoprolol hemifumarate is a selective β1-AR adrenergic antagonist. Possesses β1/β2 selectivity of approximately 100-fold and a Kd of 2-3 nM at the β1-AR (β1 receptor). |
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| DC10094 |
(±)-SLV319(Ibipinabant)
Featured
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(±)-SLV 319 is a potent and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. |
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| DC20209 |
Octodrine hydrochloride
Featured
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Octodrine (2-Amino-6-methylheptane) is a central nervous activator that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect). |
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| DC10160 |
(1R,2S)-VU0155041 |
(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. |
-VU0155041 .gif)
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| DC10428 |
(1S,3R,5R)-PIM447 dihydrochloride |
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. |
-PIM447 dihydrochloride.gif)
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| DC22327 |
(20R)-Protopanaxdiol
Featured
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(20R)-Protopanaxdiol has protective effect on myocardial ischemia, which may be related to improving free radicals metabolism and myocardial metabolism, decreasing plasma TXA 2 levels. |
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| DC9833 |
(20S)-Protopanaxadiol
Featured
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(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer. |
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