Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > PERK
Cat. No. Product name CAS No.
DC12283 CCT020312

CCT020312 is capable of delivering potent, and eukaryotic initiation factor 2-alpha kinase 3 (EIF2AK3) selective, proliferation control and also is an activator of RNA-like endoplasmic reticulum kinase (PERK).

324759-76-4
DC7142 GSK2606414 Featured

GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.

1337531-36-8
DC7431 ISRIB Featured

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM.

1597403-47-8
DC28501 AMG PERK 44

AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively.

1883548-84-2
DC28683 PERK-IN-3

PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM.

1337532-08-7
DC28778 PERK-IN-2

PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM.

1337531-83-5
DC41027 MK-28

MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.

864388-65-8
DC47924 PERK-IN-4

PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states.

1337531-89-1
DC49564 PERK-IN-5

PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model.

2616821-91-9
DC70309 cis-ISRIB

cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, displays significant enhancement in spatial and fear-associated learning.ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR).

548470-11-7
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