| DC12283 |
CCT020312 |
CCT020312 is capable of delivering potent, and eukaryotic initiation factor 2-alpha kinase 3 (EIF2AK3) selective, proliferation control and also is an activator of RNA-like endoplasmic reticulum kinase (PERK). |
|
| DC7142 |
GSK2606414
Featured
|
GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM. |
|
| DC7431 |
ISRIB
Featured
|
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. |
|
| DC28501 |
AMG PERK 44 |
AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. |
|
| DC28683 |
PERK-IN-3 |
PERK-IN-3 is a potent PERK inhibitor with an IC50 of 7.4 nM. |
|
| DC28778 |
PERK-IN-2 |
PERK-IN-2 is a potent PERK inhibitor with an IC50 of 0.2 nM. |
|
| DC41027 |
MK-28 |
MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice. |
|
| DC47924 |
PERK-IN-4 |
PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. |
|
| DC49564 |
PERK-IN-5 |
PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model. |
|
| DC70309 |
cis-ISRIB
Featured
|
cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, displays significant enhancement in spatial and fear-associated learning.ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR). |
|
| DC73218 |
HC-5404 |
HC-5404 (LY-4) is a potent, selective and orally active inhibitor of PKR-like endoplasmic reticulum kinase (PERK, EIF2AK3) with IC50 of 1 nM. |
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