TRP Channel

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Cat. No.	Product Name	Field of Application
DCL-011	Capsaicin	>98%,Standard References
DC11502	2-APB	A membrane permeable IP3 receptor antagonist and broad TRP channels (TRPC5, TRPM2) blcoker.
DC12018	MRS 1477	A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).
DC11508	AC1903 Featured	AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model.
DC11239	AMG-333 Featured	AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.
DC7055	AMG517 Featured	AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
DC10132	AMG9810 Featured	AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM).
DC10558	ASP 7663 Featured	ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat).
DC9826	BCTC Featured	BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
DC7387	Clemizole Hydrochloride Featured	Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
DC8832	Clemizole (free base) Featured	Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
DC11280	GSK1016790A Featured	GSK1016790A is a novel and potent TRPV4 channel agonist.
DC10865	GSK2193874 Featured	GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50 of 2 nM and 40 nM for rTRPV4 and hTRPV4.
DC11416	HC-067047 Featured	HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM).
DC7213	ICILIN Featured	Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.
DC8378	Mavatrep(JNJ-39439335) Featured	Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.
DC7998	ML 204 Featured	ML 204 isa blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively).
DC7262	Optovin Featured	Optovin is a reversible photoactive TRPA1 activator.
DC10399	PAC-14028	PAC-14028 is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.
DC9636	Pyr6	Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
DC11325	RN-1734 Featured	RN-1734 is a transient receptor potential vanilloid 4 (TRPV4) antagonist, blocking calcium influx induced by the TRPV4 agonist 4α-phorbol 12,13-didecanoate with IC50 values of 2.3, 5.9, and 3.2 µM for human, mouse, and rat TRPV4, respectively.
DC8306	RQ-00203078 Featured	RQ-00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).
DC9735	SB-366791 Featured	SB-366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research.
DC9635	SB-705498 Featured	SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.
DC9722	SKF96365 Featured	SKF96365 is blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
DC9622	SN 2	SN 2 is a novel and potent small molecule activator of TRPML3 with EC50 of 1.13 uM.
DC7755	TRCP6 inhibitor(SAR7334) Featured	TRPC6 inhibitor is a potent TRPC6(Transient receptor potential cation channel, subfamily C, member 6) inhibitor.
DC11472	TRPM8 antagonist 14 Featured	TRPM8 Antagonist is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
DC28276	GSK1702934A	GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.
DC28359	Hyperforin dicyclohexylammonium salt	Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.

TRP Channel

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