Cat. No. | Product name | CAS No. |
DC11019 |
ASP3662
Featured
ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
1204178-50-6 |
DCS-019 |
(-)-Huperzine A
>98%,Standard References |
102518-79-6 |
DCJ-030 |
Galanthamine
>98%,Standard References |
357-70-0 |
DC11301 |
ALZ-801
Featured
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. |
1034190-08-3 |
DC9946 |
Lanabecestat(AZD3293,LY-3314814)
AZD3293 is a potent and selective orally active, brain-permeable BACE1 inhibitor,currently in development as a potential treatment for early Alzheimer’s disease. |
1383982-64-6 |
DC8400 |
AZD3839
Featured
AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1. |
1227163-84-9 |
DC8338 |
Azeliragon(PF-04494700,TTP488)
Featured
Azeliragon is an oral, small-molecule inhibitor of RAGE. |
603148-36-3 |
DC11105 |
Umibecestat
Featured
beta-secretase inhibitor. |
1387560-01-1 |
DC11389 |
BI 409306
Featured
BI 409306 is an inhibitor of phosphodisterase 9A(PDE9A). |
1189767-28-9 |
DC3114 |
Avagacestat (BMS-708163)
Featured
BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. |
1146699-66-2 |
DC11038 |
Bryostatin 1
Featured
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM). |
83314-01-6 |
DC10506 |
CPHPC(Miridesap)
Featured
CPHPC(GSK2315698,Miridesap) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. |
224624-80-0 |
DC8277 |
E-2012
Featured
E 2012 is a potent γ-secretase modulator. |
870843-42-8 |
DC11551 |
Elenbecestat
Featured
Elenbecestat (E2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease.. |
1388149-39-0 |
DC10490 |
GIBH-130
Featured
GIBH-130 is a novel inhibitor of neuroinflammation effective in Alzheimer’s disease models. |
1252608-59-5 |
DC5061 |
GYKI 52466 dihydrochloride
GYKI 52466 dihydrochloride is a selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. |
102771-26-6 |
DC9329 |
(±)-Huperzine A
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). |
120786-18-7 |
DC5180 |
LY2811376
Featured
LY2811376 is the first orally available non-peptidicβ-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM. |
1194044-20-6 |
DC5053 |
LY2886721
Featured
LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. |
1262036-50-9 |
DC5036 |
LY-411575
Featured
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. |
209984-57-6 |
DC9901 |
Verubecestat (MK-8931)
Featured
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase. |
1286770-55-5 |
DC11247 |
Nelonicline
Featured
Nelonicline (ABT-126) is a potent, selective α7 nicotinic receptor (nAChR) partial agonist for the treatment of cognitive impairment with schizophrenia.. |
1026134-63-3 |