| DC7524 |
Uramustine
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Uramustine (INN), also known as uracil mustard, is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.For the detailed information of Uramustine, the solubility of Uramustine in water, the solubility of Uramustine in DMSO, the solubility of Uramustine in PBS buffer, the animal experiment (test) of Uramustine, the cell expriment (test) of Uramustine, the in vivo, in vitro and clinical trial test of Uramustine, the EC50, IC50,and Affinity of Uramustine, Please contact DC Chemicals.. |
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| DC11019 |
ASP3662
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ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
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| DC11206 |
HSD-016
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HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively. |
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| DC11205 |
INU-101
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INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively. |
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| DC20787 |
(-) BI97D6
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(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively. |
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| DC12277 |
(-)-BAY-1251152
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(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. |
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| DC7818 |
(-)Blebbistatin
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(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. |
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| DC20288 |
(-)-CXL017
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(-)-CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 13.5 uM. |
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| DC9624 |
Sparteine sulfate pentahydrate
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(-)-Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. |
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| DC20149 |
(+)-Kavain
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(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABA |
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| DC11321 |
(+)-Muscarine (chloride) |
(+)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria. |
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| DC5060 |
(+)PD 128907 |
(+)PD 128907 is a potent D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes. |
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| DC20138 |
(+)-Penbutolol
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(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action. |
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| DC20209 |
Octodrine hydrochloride
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Octodrine (2-Amino-6-methylheptane) is a central nervous activator that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect). |
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| DC10160 |
(1R,2S)-VU0155041 |
(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. |
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| DC10428 |
(1S,3R,5R)-PIM447 dihydrochloride |
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. |
-PIM447 dihydrochloride.gif)
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| DC12268 |
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine hydrochloride) |
(3-Carboxypropyl)trimethylammonium chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat. |
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| DC20603 |
(5Z)-7-Oxozeaenol |
(5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively. |
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| DC10426 |
(E)-[6]-Dehydroparadol |
(E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively. |
-[6]-Dehydroparadol .gif)
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| DC9584 |
(R)-(-)-Rolipram |
(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.
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| DC9533 |
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid |
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.
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| DC22808 |
(R)-9bMS |
(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM. |
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| DC9450 |
(R)-Baclofen |
(R)-Baclofen(STX209) is a selective GABAB receptor agonist. |
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| DC10388 |
(R)-BPO-27 |
(R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM |
-BPO-27.gif)
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| DC20882 |
(R)-CE3F4 |
(R)-CE3F4 is a more potent, selective EPAC1 antagonist than the racemic CE3F4 and (S)-CE3F4, displays 10-fold selectivity for EPAC1 over EPAC2.. |
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| DC11364 |
Levocetirizine；(R)-Cetirizine (hydrochloride) |
(R)-Cetirizine is the (R)-enantiomer of the histamine H1 receptor antagonist and second generation antihistamine cetirizine. |
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| DC23692 |
(R)-DNMDP |
(R)-DNMDP (DNMDP R-form) is the R-form of is DNMDP, which is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12).. |
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| DC11952 |
(R)-DRF053 dihydrochloride |
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
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| DC20290 |
(R)-HZ05 |
(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.. |
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| DC11488 |
USP7-IN-4 |
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays. |
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