Uramustine (INN), also known as uracil mustard, is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.For the detailed information of Uramustine, the solubility of Uramustine in water, the solubility of Uramustine in DMSO, the solubility of Uramustine in PBS buffer, the animal experiment (test) of Uramustine, the cell expriment (test) of Uramustine, the in vivo, in vitro and clinical trial test of Uramustine, the EC50, IC50,and Affinity of Uramustine, Please contact DC Chemicals..

ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM.

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.

INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively.

(-) BI97D6 (BI112D1) is a potent, pan-active inhibitor of Bcl-2 family proteins with IC50 of 76, 31, 25, and 122 nM for Bcl-xL, Bcl-2, Mcl-1, and Bfl-1, respectively.

(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

(-)-CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 13.5 uM.

(-)-Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker.

(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABA

(+)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria.

(+)PD 128907 is a potent D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action.

(1,5-dimethylhexyl)ammonium chloride is used as a systemic acidifying agent in treatment of severe metabolic alkalosis, in oral acid loading test to diagnose distal renal tubular acidosis, to maintain the urine at an acid pH in the treatment of some urina

(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

(3-Carboxypropyl)trimethylammonium chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.

(5Z)-7-Oxozeaenol is a potent and selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.

(E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.

(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.

(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.

(R)-Baclofen(STX209) is a selective GABAB receptor agonist.

(R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM

(R)-CE3F4 is a more potent, selective EPAC1 antagonist than the racemic CE3F4 and (S)-CE3F4, displays 10-fold selectivity for EPAC1 over EPAC2..

(R)-Cetirizine is the (R)-enantiomer of the histamine H1 receptor antagonist and second generation antihistamine cetirizine.

(R)-DNMDP (DNMDP R-form) is the R-form of is DNMDP, which is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12)..

(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively.

(R)-HZ05 is a potent DHODH inhibitor with IC50 of 11 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..

(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.

(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases.

(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.

(S)-4CPG, also known as (S)-4-Carboxyphenylglycine, is a novel orally active metabotropic glutamate receptor 1 antagonist.

(S)-BAY-293 (BAY293 S-enantiomer) is the S-enantiomer of BAY-293 as a negative control compound..

(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.

(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

(S)-Metolachor, a derivative of aniline, is a major pesticide in use.

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).

(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM..

(Z)-4-hydroxy Tamoxifen is a major phase I metabolite of tamoxifen, a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.

(Z)-Mutagenic Impurity of Tenofovir Disoproxil is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucia

.Valemetostat is an antineoplastic agent.

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Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects.

Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).

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1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases.

1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation with IC50 value to be estimated in low micromolar range.

1,2-Dipalmitoyl-sn-glycerol 3-phosphate is a phosphatidic acid.

1,3-Diaminopropane, a three carbon diamine, is an ornithine decarboxylase inhibitor.

103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.

10-Hydroxydecanoic acid (NSC 15139) is a saturated fatty acid of 10-hydroxy-trans-2-decenoic acid from royal jelly, with anti-inflammatory activity.

10-NCP (10-DEBC) is a potent neuronal autophagy inducer and increases TDP43 clearance, a reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 uM).

17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.

1835F03 is a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus, inhibits the growth of a panel of S aureus strains (MIC=1-3 ug/mL), including clinical MRSA isolates..

1-Azakenpaullone is a potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC₅₀ = 18 nM).

1E7-03 is a small molecule targeting the RVxF interacting site on PP1, inhibits HIV-1, Ebolavirus (EBOV), and Venezuelan equine encephalitis virus (VEEV, EC50=0.6 uM).

1-methyl-7-nitroisatoic anhydride is a reagent that detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.

2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfideintercalating cross-linking reagent.

2,2'-Cyclouridine is a research tool for antiviral and anticancer studies.

2,4-Pyrimidinediamine with linker is a patent compound in WO2013055780A1, Page 71; multikinase inhibitor and has a -NH2 terminal linker for further synthesis.

20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein, binds at a site distinct from the canonical cyclopamine binding site.

20-O-Acetylingenol-3-angelate is a diterpene ester that has been found in E. peplus and a derivative of ingenol-3-angelate

22-Azacholesterol is the first small molecule inhibitor that inhibits Hedgehog (Hh) signaling by binding the oxysterol-binding site of Smo, inhibits Sonic Hedgehog (Shh) signaling with IC50 of 3 uM in NIH-3T3 cells..

25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

2-Aminoethanethiol (cysteamine) is a radiation-protective agent that oxidizes in air to form cystamine.

2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays.

2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM.

2'-Deoxyadenosine monohydrate is a deoxyribonucleoside. A building block in the chemical synthesis.

2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats.

2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots possesses acaricidal property. It could be used in the preparation of 4’-methyl-2’-[(p-tolylsulfonyl) oxy] acetophenone.

2-NBDG is a fluorescent indicator for direct glucose uptake measurement and also is an indicator of cell viability.

2''-O-Rhamnosylicariside II is a flavonoid glycoside compound and might be beneficial for improving postmenopausal osteoporosis.

2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 µM; IC50 = 5.1 µM).

2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid that is slightly soluble in water. It has a pleasant floral odor and also an autoantibiotic produced by

3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay

3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables.

3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Anti-apoptotic effe

3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin and could be found in children with the syndrome of hepatic ductular hypoplasia.

3-Bromo-7-Nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, is also potent against iNOS, inhibits rat nNOS, bovine eNOS, and rat iNOS with IC50 of 0.17, 0.86, and 0.29 uM..

3-Cyanochromone is a potent gram-negative bacteria WcbL protein inhibitor with IC50 of 28 uM in a competitive enzyme-inhibition model, shows inhibition constants Ki of 10 uM..

3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity.

3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.

3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM.

3-Methoxyphenylacetic acid is a monocarboxylic acid.

3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.

4-BBPB maleate is a highly potent agonist of σ1 receptor with Ki of 0.8 nM.

4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.

4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.

4-CPPC is the first reversible and selective inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (MIF-2) with Ki of 33 uM, 13-fold selectivity for human MIF-2 versus human MIF-1.

4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.

4-Hydroxyquinazoline is a PARP inhibitor with a high potency for PARP-1 and no effects on enzymes other than PARP.

4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC50 of 19 nM for human P450 1B1-dependent EROD.

4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.

5,6-Dihydro-5-azacytidine|cas 62488-57-7

5-bromoindole is an important pharmaceutical chemical intermediate and a potential inhibitor of glycogen synthase kinase 3 (GSK-3).

5'-Cytidylic acid is a nucleotide that is used as a monomer in RNA.

5-Formyl-2-pyrimidinecarbonitrile is a chemical intermidate..

5'-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

5-Iodotubercidin (Itu) has been shown to inhibit mitogen-activated protein kinase (ERK2) (Ki = 525 nM), adenosine kinase (ADK) (Ki = 30 nM), casein kinases 1 & 2 (CSNK1A1 & CSNK2A1), protein kinase A (PKA) and insulin receptor kinase (IC50 ranging from 0.

5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.

5MPN a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.

5-NITP (5-nitro-indolyl-2'-deoxyribose triphosphate) is a non-natural nucleotide that inhibits ribonucleotide reductase (hRR) with IC50 of 170 uM, demonstrates anti-cancer effects against leukemia cells by altering cell-cycle progression..

5-R-Rivaroxaban is (R) enantiomer of Rivaroxaban.

6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes.

6-Ethylthioinosine (6-ETI.

6-FABA (6-Fluoroanthranilic Acid) is a small-molecule inhibitor of MTB tryptophan synthesis that converts Mtb into a tryptophan auxotroph and restores the efficacy of a failed host defense.

6-Fluorescein isothiocyanate(6-FITC) is a derivative of fluorescein used in wide-ranging applications including flow cytometry.

6-Hydroxybentazon is a phase I metabolite of bentazone, and bentazone is a chemical for use in herbicides.

6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.

6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.

7,8-Dihydroxyflavone acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).

7-BIA is a small molecule 7-butoxy illudalic acid analog that targets receptor-type protein tyrosine phosphatase D (PTPRD, IC50=1-3 uM) with some specificity.

7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3.

7DG (7-Desacetoxy-6,7-dehydrogedunin) is a selective inhibitor of protein kinase R (PKR) that directly interact with the C-terminal of PKR.

8-Hydroxy-efavirenz is the primary metabolite of the antiretroviral drug Efavirenz, stimulates the glycolytic flux in cultured rat astrocytes.

8-O-Acetyl shanzhiside methyl ester (ND01) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang.

A 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ)..

A 2-cyanoaziridine derivative with antitumor activity in some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma.

A 385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM, displays >80-fold selectivity over Bcl-2 (Ki=64 nM).

A 4′-azidocytidine analogue that shows anti-HCV activity..

A 4′-azidocytidine analogue that shows anti-HCV activity..

A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively.

A angiotensin-converting enzyme (ACE) inhibitor for treatment of hypertension, heart failure, and after heart attacks..

A anti-HIV-1 compound that interferes with HIV-I integrase binding to viral DNA..

A benzodiazepine inhibitor that directly interacts with RUNX1 and CBFβ, represses RUNX1/CBFβ-dependent transactivation in reporter assays.

A benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13).

A benzophenone tetracarboxylic derivative that can improve the activity and stability of alkaline phosphatases from psychrophilic and mesophilic organisms..

A bioactive, specific small molecule that targets RNA of the expanded repeat (r(GGGGCC)exp) with Kd of 9.7 uM.

A biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell migration.

A bis-anthracycline and melanoma selective agent that demonstrates anti-melanoma activity at low nanomolar concentrations.

A BIX-01294 derivative that inhibit malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.

A B-Raf inhibitor, pyrazine and pyrrolo[2,3-b]pyridine derivatives, useful in the treatment of cancer and proliferative diseases.

A broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM(biochemical assay), and 0.31 nM (cell function assay).

A broad-spectrum natural antifungal compound that acts as a selective and highly potent fungal Pkc1 kinase inhibitor.

A broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS.

A CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively).

Norverapamil HCl is a calcium channel blocker. It is the main active metabolite of verapamil.

A carbamate insecticide that acts as a fast-acting cholinesterase inhibitor..

A carbamate insecticide that acts as a fast-acting cholinesterase inhibitor..

A carboxylic acid amide (CAA) fungicide..

A cardioselective beta blocker for the treatment of hypertension and arrhythmias..

Acebutolol HCl is a cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.

A cell differentiation inducer that inhibits activation of NF-κB function, Akt and ERK/MAPK cascade.

A cell permeable CBP bromodomain inhibitor with Kd of 19 uM.

A cell permeable CBP bromodomain inhibitor with Kd of 19 uM.

A cell-permeable benzochromene that selectively impairs the viability and growth of IGF2-overexpressing hepatocellular carcinoma cells, binds to MFP-2, stimulates the expression of IGFBP-1 and SOCS-3 through activation of STAT6.

A cell-permeable inhibitor of the KIX-KID interaction and CREB-mediated gene transcription (IC50=2.26 uM).

A cell-permeable mitochondrial calcium uptake inhibitor that binds to mitochondria with high affinity (Kd=340 pM) and blocks Ca2+ uptake into mitochondria in vitro with IC50 of 184 pM.

A cell-permeable peptide inhibitor of JNK kinase.

A cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle).

A cell-permeable, small molecule inhibitor of the transcription factor STAT5 that exhibits anticancer activity and inhibits the growth of A549, HL-60 and K562 cells with IC50 of 8, 5 and 8 uM, respectively..

A cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).

BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.

A cellular cholesterol modifier that can form soluble inclusion complex with cholesterol.

A ceramide analog that inhibits glucosylceramide synthase (GCS), reduces the synthesis of sphingosine and its derivatives, increases cellular ceramide, and induces cell cycle arrest. .

A cerebral vasodilator that acts as a calcium blocker.

A chemical probe that consists of Ibrutinib linked to biotin via a long chain linker, has IC50 of 0.755-1.02 nM for Btk kinase.

A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.

Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

A clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux.

A clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux.

A combination of clofibrate and niacin, used to treat hyperlipidaemias

A combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM).

A competitive inhibitor of HMG-CoA reductase that acts as a lipid-lowering agent for prevention of events associated with cardiovascular disease..

A competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assay.

RU-TRAAK-2 is a completely reversible TRAAK inhibitor, shows no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2).

A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.

A coumarin-based HIV-1 viral protein R (Vpr) inhibitor, inhibits Vpr-dependent viral infection of human macrophages.

A coumarin-based HIV-1 viral protein R (Vpr) inhibitor, inhibits Vpr-dependent viral infection of human macrophages..

A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry, also is the first small molecule prion protein (PrP) ligand capable of inhibiting Aβ binding.

BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.

A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines.

A cytotoxic agent used in antibody-drug conjugates

A derivative of 8-hydroxyquinoline that has selectivity for rescuing the distinct toxicities caused by the expression of TDP-43, α-synuclein or polyglutamine proteins.

A derivative of EDTA that chelates iron and reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals.

A derivative of the antifungal drug itraconazole (ITA) as an inhibitor of MFB cell fate in resident fibroblasts derived from multiple murine and human tissues.

A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist.

A des acryl analogue of AZD9291 that is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant..

A diastereomer form of Taranabant, which is a potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist.

A dipeptide antibiotic that inhibits the initiation of protein synthesis.

A direct soluble guanylate cyclase (sGC) stimulator that acts independently of nitric oxide (NO).

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM.

A drug-like small molecule that prevents aminoglycoside-induced hair cell death in zebrafish and in mammals..

A drug-linker conjugate for Antibody-drug conjugates (ADCs) by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the cleavable peptide Val-Cit-PAB..

A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.

A dual antagonist of TP1 and EP4 receptors that inhibit TXA2-induced platelet aggregation with IC50 of 0.26 uM.

A dual inhibitor of E selectin and CXCR4 with IC50 of 3.6 uM and 1.1 uM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice.

A dual inhibitor of E selectin and CXCR4 with IC50 of 4.1 uM and 30 nM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice.