K9 is a novel ionizable lipid designed by the multi-objective AI model MOLEA. Its core function is to enable tissue-selective mRNA delivery. When formulated into Lipid Nanoparticles (LNPs), K9 can preferentially deliver mRNA efficiently to articular chondrocytes while significantly reducing delivery to hepatocytes. This facilitates targeted drug delivery for conditions like osteoarthritis and lowers the risk of off-target effects in the liver. In vitro experiments confirm that K9-LNPs promote endosomal escape and efficient expression of mRNA in chondrocytes. Its targeted delivery efficiency is further enhanced by optimizing the LNP formulation (e.g., lipid composition ratios) using a Design of Experiment (DoE) approach. In vivo studies show that after intra-articular injection, K9-LNPs exhibit high biodistribution and gene expression in the knee joint, with limited distribution in major organs like the liver. Therefore, K9 represents an advanced, rationally designed LNP component for achieving joint tissue-specific therapy, providing a key tool for developing targeted mRNA therapeutics.

ZINC13407541 is a small molecule antagonist for FGF23, inhibits FGF-23 signaling with IC50 of 0.45 uM.

5-Carboxytetramethylrhodamine can be used as a fluorescent probe of nucleic acids and proteins. 5-Carboxytetramethylrhodamine displays excitation maxima of 558 nm and an emission maximum of 586 nm.

Mal-Exatecan is a Mal (Maleimide) modified Exatecan. Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM).

Icatibant is a peptidomimetic drug consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors. It has been approved by the European Commission for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency.

β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.

Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation.

Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation.

L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme.

Iodixanol is a contrast agent. It is commonly used as a contrast agent during coronary angiography. It is the only iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H2O—the same as blood.

Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.

Midecamycin is a naturally occurring 16-membered macrolide that fits under the category of acetoxy-substituted macrolide antibiotics. In this molecule, an acetoxy group is substituted on the position 9 of the 16-member ring and on position 4 of the terminal sugar.

Methylisothiazolinone, also known as MIT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.

Alizarine Yellow R is a yellow colored azo dye made by the diazo coupling reaction.

Agmatine Sulfate is a neurotransmitter and neuromodulator, inhibiting N-methyl-D-aspartate (NMDA), nicotinic acetylcholine receptors nitric oxide synthase, calcium channels and certain serotonin receptors, activating imidazoline receptors.

1-Decanol is used in the production of plasticizers, lubricants, surfactants and solvents. It is also used to study the thermal properties of polymer-monolithic stationary phases. Further, it is used to enhance homomeric glycine receptor function. In addition to this, it is used in daily flavor, food flavor and cosmetics.

Free Cyanine3 carboxylic acid (Cy3? carboxylic acid analog), non-activated dye. Non-sulfonated reagent, with good solubility in organic solvents, and limited aquous solubility. The dye can be used as a non-reactive fluorophore, for control experiments, and for calibration.

m-PEG3-alcohol is a PEG derivative containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

t-Boc-N-Amido-PEG3-amine is a PEG derivative containing an amino group and Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. PEG Linkers may be useful in the development of antibody drug conjugates.

Dibenzylamine is a component of Potent neurogenic agent.

Aca-Bio is a specialized chemical probe designed for the specific enrichment and detection of lysine acetoacetylation (Kacac). Its core architecture consists of a hydroxylamine group, a polyethylene glycol (PEG) linker, and a biotin tag. Functionally, the hydroxylamine group selectively reacts with the unique ketone carbonyl moiety of Kacac under physiological conditions to form a stable, covalent oxime bond. This specific targeting allows Aca-Bio to accurately label Kacac-modified peptides in complex biological samples. Subsequently, the attached biotin tag enables efficient isolation of these labeled peptides via streptavidin-mediated affinity purification. A critical feature of Aca-Bio is its pH-responsive reversibility; the oxime bond remains stable at neutral pH but undergoes controlled cleavage in acidic environments. This allows for the gentle and effective elution of enriched peptides, facilitating subsequent mass spectrometry analysis. By overcoming the limitations of traditional antibody-based methods, Aca-Bio serves as a highly specific and sensitive tool for global Kacac substrate profiling.

TCO-NHS ester is an amine-reactive reagent containing the TCO moiety and a NHS ester. This reagent can be used to modify an amine-containing molecules. The specially formulated crystalline producty enables easy handling andan extended shelf life. TCO-NHS Ester is supplied as single axial (major) diastereomer.

Undecylenic acid is a fatty acid with a terminal double bond. Undecylenic acid is an active ingredient in medications for skin infections, and to relieve itching, burning, and irritation associated with skin problems.

Thiazolylalanine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

3-Hydroxyacetophenone (m-Hydroxyacetophenone) is a hydroxy-substituted alkyl phenyl ketone and also a plant defensin in carnations.

Calcium Stearate as an Effective Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis.

4-Phenylbutyric acid is an antineoplastic agent.

2-Acetylpyrazine is a pyrazine and a ketone. It is a yellow-brown powder at room temperature.

N-Monoacetylcystine is an antidote for paracetamol poisoning. It is also an antioxidant, used in the treatment of influenza A virus pandemic. N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse.