| DC11163 |
AST-3424
Featured
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AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent. |
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| DC10434 |
Bisantrene
Featured
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Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. |
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| DC9095 |
Carboplatin
Featured
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Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism. |
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| DC2099 |
cis-Diaminedichloroplatinum
Featured
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Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. |
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| DC9013 |
Cyclophosphamide
Featured
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Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
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| DC9014 |
Ifosfamide |
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. |
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| DC9050 |
Melphalan
Featured
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Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. |
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| DC4182 |
Temozolomide
Featured
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Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer. |
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| DC8935 |
Mitomycin C
Featured
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Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. |
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| DC9298 |
thiotepa
Featured
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N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group. |
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| DC5885 |
Oxaliplatin
Featured
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Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the eff |
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| DC7689 |
Evofosfamide(TH-302)
Featured
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TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism. |
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| DC10611 |
Trabectedin
Featured
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Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo. |
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| DC40052 |
Melflufen hydrochloride |
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells. |
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| DC40248 |
4-Hydroperoxy cyclophosphamide |
4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide is used to treat lymphomas and autoimmune disorders. |
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| DC40300 |
Illudin M
Featured
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Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus olearius mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities. |
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| DC40328 |
PIP-199
Featured
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PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM). PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics. |
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| DC40446 |
Duocarmycin DM |
Duocarmycin DM, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. |
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| DC40772 |
Bendamustine |
Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties. |
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| DC40884 |
Phenylacetic acid mustard |
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil. Chlorambucil is an alkylating agent with antitumor activity.
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|
| DC41032 |
Phosphoramide mustard |
Phosphoramide mustard is the major metabolite for Cyclophosphamide, with anticancer activitiy. Phosphoramide mustard induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response.
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|
| DC41033 |
Phosphoramide mustard (cyclohexanamine) |
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide, with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response.
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|
| DC41170 |
Busulfan-D8 |
Busulfan-D8 is a deuterium labeled Busulfan. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent. Busulfan forms both intra- and interstrand crosslinks on DNA. In mammals, Busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses. |
|
| DC42454 |
Treosulfan
Featured
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Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines. |
|
| DC45331 |
PR-104A |
PR-104A (SN 27858) is the alcohol metabolite of phosphate prodrug PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL). |
|
| DC45552 |
PR-104 |
PR-104 is a selective hypoxia-activated DNA cross-linking agent can be used for the research of multiple tumor xenograft models. PR-104 as a nitrogen mustard pre-prodrug is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A. |
|
| DC45553 |
PR-104 sodium |
PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent can be used for the research of multiple tumor xenograft models. PR-104 (sodium) as a nitrogen mustard pre-prodrug is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A. |
|
| DC46050 |
Lurbinectedin D3 |
Lurbinectedin D3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively. |
|
| DC46283 |
Sibiromycin
Featured
|
Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine. |
|
| DC46827 |
(-)-Irofulven |
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity. |
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