| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC7736 | 6H05 Featured | 6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C). |
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| DC11622 | MAP3K14-IN-173 | A novel potent MAP3K14 kinase inhibitor with IC50 of 1.8 nM (NIK autophosphorylation). |
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| DC11610 | AKS1-IN-19 | A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3. |
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| DC11959 | PD 184161 Featured | A potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM. |
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| DC11558 | DLK-IN-14 | A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM. |
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| DC10417 | Acumapimod (BCT197) Featured | Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α. |
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| DC10048 | APS-2-79 Featured | APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
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| DC9808 | APS-2-79 hydrochloride Featured | APS-2-79 is a novel modulator of KSR-dependent MAPK signalling,KSR2,IC50=120 nM |
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| DC10738 | ARS-1323 Featured | ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
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| DC10725 | ARS-1620 Featured | ARS-1620 is a covalent compound with high potency and selectivity for KRAS-G12C. |
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| DC12031 | ARS-1630 Featured | ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
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| DC8816 | ARS-853 Featured | ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation. |
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| DC10781 | ASK1-IN-1 Featured | ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4. |
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| DC10649 | AX15836 Featured | AX15836 is a highly potent and selective ERK5 inhibitor. |
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| DC12376 | AZ304 Featured | AZ304 is a novel potent, dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF and wild type CRAF with IC50 of 79 nM, 38 nM and 68 nM, respectively. |
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| DC10985 | AZ6197 | AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively. |
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| DC11481 | AZD-0364 Featured | AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM. |
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| DC1069 | AZD6244 (Selumetinib,ARRY-142886) Featured | AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM. |
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| DC7077 | AZD8330(ARRY-424704; ARRY-704) Featured | AZD8330(ARRY-424704; ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. |
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| DC10994 | Balamapimod | Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential.. |
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| DC12278 | Belvarafenib Featured | Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. |
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| DC7107 | BI-78D3 Featured | BI-78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. |
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| DC8401 | BI-847325 Featured | BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. |
|
| DC7098 | BI-D1870 Featured | BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC50s are 31 nM, 24 nM, 18 nM, 15 nM, respectively. |
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| DC7836 | Doramapimod (BIRB-796) Featured | BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ. |
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| DC5002 | BIX02188 (BIX 02188） Featured | BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
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| DC5003 | BIX02189 (BIX 02189） | BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
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| DC7718 | B-Raf IN 1 Featured | B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM). |
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| DC8921 | B-Raf inhibitor 1 Featured | B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively. |
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| DC7008 | BRAF inhibitor Featured | BRAF inhibitor is a potent BRAF inhibitor. |
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