A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.

CM-11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation.

A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.

A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM)..

A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells).

ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader with Kd values of 4.7, 7.6, 7.6 nM against bromodomain 2, 3 and 4, respectively.

ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.

BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.

BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.

BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK.

CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1].

dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM.

dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2..

dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM, and has antitumor activity.

dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement).

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.

MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).

MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC).

RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors; blocks mTOR signaling of the F2108L mTOR and M2327I mTOR drug resistant mutants; RapaLink-1 is more potent mTOR inhibitor than rapamycin.

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.

THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines.

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent.

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn.

dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker.

SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity.

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, extracted from patent WO2018106870A1.

KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF.

Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG linker.

KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1.

(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to VHL and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).

GNE-987 is a highly active chimeric BET degrader. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC).

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively.

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively.

DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC). DT2216 targets BCL-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.

PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit.

PROTAC EED degrader-2 is a PROTAC targeting EED with a pKD of 9.27. PROTAC EED degrader-2 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.11) targeting the EED subunit.

UNC6852 is a selective rolycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand, with an IC50 of 247 nM for EED.

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with CRBN ligand.

ARD-266 is a a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM.

INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide. INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.

PROTAC BRD4 Degrader-1 is an efficacious BRD4 degrader with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression.

PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1.

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM.

PROTAC BRD4 Degrader-3 (compound 1004.1) is an efficacious PROTAC BRD4 degrader.

GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].

PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder.

PROTAC BET Degrader-10 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, with a DC50 of 49 nM.

ARCC-4 is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5?nM. ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy.

N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1.

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1. PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM.

DBCO-C2-SulfoNHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis.

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines.

6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity.

PROTAC KRASG12C Degrader-LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. PROTAC KRASG12C Degrader-LC-2 is composed of a covalent KRAS G12C inhibitor MRTX849, a VHL ligand and a linker.

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1.

endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1.

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Homo-PROTAC cereblon degrader 1, is a cereblon degrader.

CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation.

PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells.

LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.

Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204

ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment.

BOC-NH-PEG2-propene is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propenyl-PEG3-Propenyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

H2N-PEG2-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Hydroxy-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-NH-PEG-Thiol (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

m-PEG750-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NH2-PEG-Strt (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

NH2-PEG-Strt (MW 3000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

m-PEG1000-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG1-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

NH2-PEG2-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG1-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-Pyrrolidine-PEG2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Br-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Br-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG9-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG10-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl acetate-PEG2-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propanol-PEG3-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propanol-PEG6-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Ethyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

PEG2-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG4-C1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG7-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG8-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-PEG4-methyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-NH-PEG1-C5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

CHO-CH2-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Tos-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

MS-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-C1-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Acid-PEG2-ethyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-C2-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Endo-BCN-Nitrobenzene is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG2-ethanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

3-Aminophenol-PEG4-methyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Hydrazide-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

endo-BCN-PEG12-NH2 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG7-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG11-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG12-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG23-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG24-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG36-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG6-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromoacetamido-PEG8-t-butyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromoacetic-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG1-NH2 hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG6-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG7-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG8-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-NH-PEG8-C2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Br-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bromo-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG6-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Glycocholic acid-PEG10-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Bis-acrylate-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG13-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG16-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG18-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG24-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG16-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

THP-PEG11-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.