| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11964 | Lys01 | A 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ).. |
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| DC11603 | SR-19871 | A novel potent ULK1 inhibitor with IC50 of 11 nM.. |
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| DC11668 | AUTEN-67 | A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14. |
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| DC11965 | Lucanthone | An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) potential antineoplastic activity, also inhibits autophagy. |
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| DC10824 | ARN-3236 Featured | ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. |
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| DC10548 | Auten-99 Featured | Auten-99 is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects. |
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| DC8730 | Cambendazol Featured | Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle. |
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| DC7113 | CZC-25146 Featured | CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. |
|
| DC8082 | CZC-54252 Featured | CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). |
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| DC7404 | DMXAA Featured | DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3. |
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| DC10194 | FMK 9a Featured | FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. |
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| DC7418 | DNL201 Featured | GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. |
|
| DC7419 | GNE-7915 Featured | GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). |
|
| DC7629 | GNE-9605 Featured | GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor |
|
| DC7852 | LRRK2 inhibitor GSK2578215A Featured | GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. |
|
| DC8648 | GSK4112 Featured | GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. |
|
| DC11258 | IITZ-01 Featured | IITZ-01 is a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. |
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| DC8379 | JH-II-127 Featured | JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
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| DC11440 | LRRK2 inhibitor 18 Featured | LRRK2 inhibitor 18(Compound 18) is a potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 4.1 nM. |
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| DC8237 | LRRK2-IN-1 Featured | LRRK2-IN-1 inhibits both wild-type and G2019S mutant LRRK2 kinase activity with IC50 values of 13 nM and 6 nM , respectively with 0.1 mM ATP in the assay. |
|
| DCAPI1570 | Hydroxychloroquine Sulphate | Lupus erythematosus suppressant as well as an antimalerial and antirheumatic. |
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| DC11172 | LV-320 | LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays. |
|
| DC10715 | LYN-1604 Featured | LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). |
|
| DC10358 | Lys01 trihydrochloride Featured | Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. |
|
| DC10508 | Lys05 Featured | Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth. |
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| DC10360 | MLi-2 Featured | MLi-2 is an a potent, highly selective, orally available, brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM. |
|
| DC10635 | MRT67307 HCl Featured | MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. |
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| DC7971 | PF-06447475 Featured | PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. |
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| DC11288 | PF-06454589 Featured | PF-06454589 is a potent and selective LRRK2 inhibitor. |
|
| DC11243 | PHY34 | PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM). |
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