Novel potent and selective DCN1-UBC12 inhibitor for anticardiac fibrotic effects, specifically targetinbg DCN1 at molecular and cellular levels, effectively reversing angiotensin (Ang) II-induced cardiac fibroblast activation

Novel PRC2 Inhibitor, Targeting EZH2-EED Interaction

Novel, Selective Histone Methyltransferase SET7 Inhibitor

Novel, Potent and Selective Histone Methyltransferase SET7 Inhibitor

Novel, Potent and Selective Histone Methyltransferase SET7 Inhibitor

Novel potent and selective TEAD autopalmitoylation inhibitor, inhibiting TEADs transcription activity and downstream gene expression

Novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction

Novel selective BTK degrader, demonstrating prolonged pharmacodynamic effects

Novel inhibitor of α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons, selectively interacting with Synaptotagmin 1

First-generation allosteric EGFR inhibitor, binding to the allosteric site of EGFR along with ATP that leads to inhibition of cell proliferation and arrest of EGFR L858R/T790M/C797S signalling

Novel activator of the GUS reporter activity, specific increasing in stumpy reporter gene expression

Novel transmission blocker of antimalarials, targeting male gametes

Potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain

Potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT) with markedly improved blood-brain barrier permeability

Novel potent and broad-spectrum antiviral agent, acting as a chain terminator for viral RNA polymerase

Novel potent blocker of mixed lineage leukemia 1 (MLL1)-WDR5 interaction, inhibiting MLL1 complex H3K4 methyltransferase activity

Novel Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia

Novel NQO1 substrate, inhibiting cancer cell (NQO1-rich A549 cell line) growth

Novel Nrf2 activator

Potent mGAT4 inhibitor

Potent and selective DDR1 receptor tyrosine kinase inhibitor

Inhibitor of nonhomologous end-joining (NHEJ) DNA repair following double strand DNA breaks induced by ionizing radiation, enhancing the effects of DNA-damaging cancer drugs like etoposide, camptothecin and doxorubicin