Novel inhibitor of the heat shock protein 70 (Hsp70) with anti-proliferative activity in breast and prostate cancer cells

Novel type I Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, binding preferentially to unphosphorylated IRAK4

Novel Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, binding preferentially to unphosphorylated IRAK4

Novel Ras homologous A (RHOA) inhibitor, potently inhibiting cell viability and migration/invasion of gastric cancer (GC) cell lines, and mouse xenografts, diversely expressing RHOA, binding affinity for RHOA was >140-fold greater than Rhosin, a nonclinic

Novel specific dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) and cyclin-dependent kinase 1 (CDK1), targeting cell cycle progression and angiogenesis

Potent non-nucleoside inhibitor of HIV-1 reverse transcriptase (NNRTIs)

Novel potent GHS-R1a agonist (EC50 (Ca ): 1.6 nM), significantly stimulating GH secretion

Novel ghrelin receptor (GHS-R1a) antagonist [IC 50 (affinity): 5 nM IC 50 (Ca ): 60 nM]

Novel partial inverse agonist of GHS-R1a (K i = 3 nM, EC 50 = 70 nM, Emax = −37%)

Novel inhibitor of viral protease function, suppressing Zika virus Infection both In vitro and In vivo

Novel Potent NS4B Inhibitor for the Treatment of Dengue Virus Infection

Novel Potent Human Adenovirus Inhibitor, showing improved anti-HAdV activity (IC50 = 0.27 μM), significantly decreasing cytotoxicity (CC50 = 156.8 μM), and lowering in vivo toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosam

Novel potent and selective IRAK1 degrader, effectively degraded cellular IRAK1 protein with a DC50 of 3 nM in HBL-1 cells

Novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase

Vascular endothelial growth factor receptor-2 (VEGF-2) kinase inhibitor

Estrogen receptor ESR1 agonist

Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor

Selective delta opioid receptor agonist as a potent and efficacious antihyperalgesic agent

Novel EthR inhibitor, boosting antituberculous activity of ethionamide

Selective androgen receptor modulator with minimal prostate hypertrophic activity stimulating sexual behavior in female rats

Histamine H3 receptor antagonist and serotonin reuptake inhibitor

Novel potent, selective, and systemically active positive allosteric modulator (PAM) of mGlu2-receptors