Novel RORγ

Cytokine release inhibitor, inhibiting production of IL-1ß, IL-8, IL-6, IL-10 and TNFalpha

Novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase

Novel orally active and selective transient receptor potential vanilloid 1 (TRPV1) antagonist

Novel inhibitor of urate transporter 1 (URAT1)

Novel K(ATP) channel opener

Specific inhibitor of factor Xa

Novel live-cell peobe of voltage-dependent structural changes of voltage-gated Kv2.1 channels

Novel neuroprotective agent, improving cognitive performances in a transgenic mouse model of AD

Novel BET selective inhibitor, targeting BRD4

Potent cannabinoid (CB) receptor agonist

Novel potent stimulator of glucagon-like peptide-1 (GLP-1) secretion in vitro, also potently stimulating Ca(2+) influx through TRPA1 cation channels, being one of the most potent non-electrophilic TRPA-1 channel agonists

Novel potent mitochondrial pyruvate carrier (MPC) inhibitor to treat hair loss

Novel BH3 α-helix mimetic, inducing apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak

High-affinity partial agonist of the vanilloid receptor

Potent TRPV1 agonist

Potent vanilloid receptor (VR1) agonist

Selective modulator of GABAA receptors containing the α5 subunit

Novel β-Glucocerebrosidase modulator, promoting dimerization of β-glucocerebrosidase and revealing an allosteric binding site, stabilizing wild-type and N370S mutant GCase and increases GCase abundance in patient-derived fibroblast cells

Novel irreversible β-Glucocerebrosidase modulator

Inhibitor of all three monoamine transporters

Potent, highly selective, and irreversible ABHD6 Inhibitor