Novel inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain

Peptide metabolite

Novel PI 3-kinase delta inhibitor

Brain penetrant high affinity α1A-adrenoceptor ligand

Novel potent and selective hA2A receptor antagonist

Novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively

Novel, potent, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors

Novel potent and selective LMP2 inhibitor, also inhibiting mouse 20S proteasomes

Novel β2-specific inhibitor, potently targeting both β2c and β2i, displaying moderate trypanocidal activity

Novel potent β2c-specific inhibitor, displaying moderate trypanocidal activity

Novel β2i-specific inhibitor, displaying moderate trypanocidal activity

Potent and selective adenosine A2A receptor antagonist

Potent mGlu5 receptor positive allosteric modulator (PAM)

A1 adenosine receptor antagonist

Human adenosine A1 receptor antagonist

Hybrid ortho/allosteric ligand of the adenosine A(1) receptor

Thiazolidine-containing cyclic peptide antibiotic, suppressing growth of species of disease-causing bacteria in that part of the human microbiome

Novel inhibitor of heat shock protein 90 (Hsp90)

Immune modulator with SARS-CoV-2 antiviral activity via a multi-target mechanism including localized, self-limiting reactive oxygen species (ROS) scavenging activities that were demonstrated in a model of lipopolysaccharide (LPS)-induced joint inflammatio

Novel Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma

Novel selective LXRβ agonist, reducing total brain Aβ

Novel Manassantin A Derivative, Inhibiting Hypoxia-Inducible Factor 1 and Tumor Growth