Novel potent and selective agonist activity for S1PR4

Novel selective sigma 1 receptor (S1R) antagonist, exhibiting potent binding affinity for S1R, high selectivity over S2R and 87 other human targets, acceptable in vitro metabolic stability, slowing clearance in liver microsomes, and excellent blood-brain

Potent and selective ligand of imidazoline 1 receptor (I1R)

Potent and selective ligand of imidazoline 1 receptor (I1R)

Potent activator of the AMP-activated protein kinase (AMPK)

Potent quinone reductase 2 (QR2) inhibitor

alpha2-Adrenoceptor Antagonist, Norepinephrine Transporter (NET) Inhibitor, Serotonine Transporter (SERT) Inhibitor

Potent and selective inhibitor of constitutive Stat3 DNA-binding and transcriptional activities

Novel modulator of the retrograde signaling including cellular responses to hypoxic and oxidative stress, selectively eliminating superoxide production by complex III without altering oxidative phosphorylation

Potent inhibitor of glucose-6-phosphate translocase (G6P T1)

Novel glucokinase (GK) activator

Novel glucokinase (GK) activator

Dual PPARα/γ agonist

Novel Analogue of SUN-B8155, acting as a cell active and functionally-relevant agonist of calcitonin receptor (CTR), inducing different Gs or arrestin activities through CTR

Partial benzodiazepine inverse agonist, showing antidepressant-like pharmacological activity and acting as a cognitive enhancer

Novel ileal Na /bile acid cotransporter inhibitor

Peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibiting gastrointestinal motility with no effect on experimental colitis in mice

Irreversible and nonselective Monoamine_oxidase_inhibitor>monoamine oxidase inhibitor (MAOI)

Novel Smoothened receptor agonist

Novel clickable HDAC inhibitor, selectively labeling HDAC complex proteins

Novel Endogenous Reactive oxygen species (ROS)-activated HDAC inhibitor prodrug, demonstrating selective activity against multiple cancer cell lines such as HeLa, MCF-7, MDA-MB-231 and B16-F10, while remaining benign to non-cancer cells

Natural α-glucosidase inhibitor