PKM2 activator, potently inhibiting proliferation of cancer cells in media lacking serine

PKM2 activator, potently inhibiting proliferation of cancer cells in media lacking serine

Novel highly selective SGK1 inhibitor with a highly optimized profile suitable for oral dosing as a potentially disease-modifying agent for osteoarthritis

Novel Potent SGLT1/2 Dual Inhibitor

Novel inhibitor of the CML mutant Bcr-AblT315I, preempting in vitro resistance when combined with nilotinib or dasatinib.

Selective agonist of GABA A receptors α5 subunit

Potent and selective agonist of GABAA receptors α5 subunit

Novel potent sEH inhibitor, effectively blocking key angiogenic properties of human retinal endothelial cells (HRECs), inhibiting choroidal sprouting and significantly suppressing CNV lesion volume

Novel inhibitor of endothelial cell growth

Novel selective inhibitor of the generation of IL-5-producing Th2 cells and induction of active histone modifications at the IL5 gene locus during Th2 cell differentiation

Stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypassing drug resistances and synergizing cancer therapies in human leukemia cell

First in Class Hypoglycemic Agent with Extra-Strong Action, increasing insulin sensitivity, improving glucose tolerance, reducing fasted insulin level and insulin sensitivity, decreasing total body and interscapular fat mass and also increasing the activi

Novel Selective Human ER Partial Agonist (ShERPA)

Selective inhibitor of cancer cell growth, exerting chemoprevention activity without evidence of toxicity

Novel Inhibitor of Phospho-STAT3 Through Induction of Protein Tyrosine Phosphatase PTPN6

Novel potent stabilizing ligand for FKBP-derived destabilizing domains

Cystathione gamma lyase (CSE) inhibitor, inhibiting H2S production and L-cysteine-induced relaxation of rat aortic rings ex vivo

Antineoplastic antibiotic

Inhibitor of shp2 protein tyrosine phosphatase (PTP)

Highly Potent and Peripheral Nervous System-Restricted KOR Agonist

Novel cognitive enhancer; Nootropic agent

Novel direct HIV-1 Nef antagonist with antiretroviral activity