Novel H2 receptor agonist, functionally stimulating human cardiac H2 receptors in vitro and in vivo

Novel USP30 inhibitor, increasing Ub-TOM20 with an EC50 of 2.45 mM and inducing the maximal Ub-TOM20

Novel kidney urea transporter UT-A1 inhibitor

Novel

Quorum sensing modulator as a LasR antagonist

Non-immunosuppressive immunophilins ligand, demonstrating enhanced neuroregeneration in the peripheral nervous system and CNS

Novel Long Residence Time Superior Inhibitor of the Vasopressin V2 Receptor

Novel Mycobacterium Tuberculosis VapC-Activating Stapled Peptide, successfully penetrated Mycobacterium smegmatis cell membranes and exerted bactericidal activity at a minimum inhibitory concentration that inhibited 50% of the isolates (MIC50) < 6.25 μM

Novel potent inhibitor of FGFR4 kinase activity

Specific inhibitor of tissue Kallikrein>kallikrein

Selective 5-HT2C receptor full agonist

Orally acting antinociceptive muscarinic agonist

Prodrug of ganciclovir for treatment of cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant

Natural pseudo-aminosugar

Novel prodrug of luciferin to mimic the transport and activation of valacyclovir, , being a robust and functional determinant of VACVase activity

Novel selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability

Novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice

Partial α4ß2 nicotinic receptor agonist and α7 full agonist

Natural inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL 2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively, also inhibiting PKC β1 activity with an IC50 value of 36.2 μM

Novel anticryptosporidial agent, acting as a toll-like receptor-2 (TLR2) antagonist

Novel potent TLR‐4 activation inhibitor, attenuating the expression of fibrosis hallmark genes collagen, fibronectin (FN) and transforming growth factor β (TGF‐β) in kidneys and improved albumin/creatinine ratio with higher efficacy

Novel potent inhibitor of VDAC1, directly interacting with purified VDAC1 and reducing its channel conductance