Novel non-peptidic highly potent, soluble and selective NPY Y2 antagonist

Novel, selective, soluble non-​peptidic NPY Y2 receptor antagonist with enhanced CNS exposure

Selective Rho-associated kinase (ROCK) inhibitor

Tamoxifen-analog that Suppresses Glial L-Glutamate Transport Activity without Interaction with Estrogen_receptor>Estrogen Receptors

Novel Inhibitor of Antiapoptotic Bcl-2 Family Proteins

Novel GPR119 Agonist, improving glucose tolerance and augmenting the glucose lowering effect as well as the plasma level of active GLP-1 in normal mice in combination treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor

Novel glucokinase activator, significantlt decreasing in blood glucose levels with no adverse effects on serum lipids or body weight

Novel dual action combretastatin A-4 (CA-4) prodrug, releasing CA-4 through a disulfide bond cleavage mechanism and containing a near-infrared (NIR) fluorophore

Novel salt inducible kinase (SIK) inhibitor, increasing bone formation and bone mass

Novel, Orally Active Bioavailable Inhibitor of VEGFR2 Signaling with Potent Antiangiogenic Activity and Antitumor Efficacy

Novel Inducer of Apoptosis in Human Colorectal Cells via Mitochondrial Apoptosis Pathway, Inhibiting Tumor Growth

Novel non-analogous leukotriene agonist

Selective growth inhibitor of endothelial cells

YM-244769 is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice.

Potent and selective mGLu1 antagonist

Novel AMPA receptor antagonist

Potent and selective microbicidal agent against wild type (wt) HIV-1, NNRTI-, NRTI-, PRI-resistant mutants

Water-soluble analog of YNT-707, acting as a potent orexin 1 receptor (OX1R) antagonist

Novel potent orexin 1 receptor (OX1R) antagonist

DNA-intercalating dye as sensitive amyloid probe

Novel Proteasome Inhibitor, Enhancing Cisplatin Cytotoxicity in Cisplatin-Resistant Human Ovarian Cancer Cells, inducing cell cycle arrest on G2 phase in MCF-7 cells via ERα and PI3K/Akt pathways

Selective A 2A receptor agonist