Novel Sirtuin1 Activator, Down-Regulating Sclerostin and Rescuing Ovariectomy-Induced Bone Loss

Novel potent SIRT1 activator

Novel selective CXCR2 antagonist

Novel potent inhibitor of Staphylococcus aureus sortase A (SrtA)

Novel antiestrogen, lacking estrogenic and genotoxic actions

Potent ß-amyloid aggregation inhibitor; Antioxidant

Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO)

Non-selective potent dopamine reuptake inhibitor

Non-selective potent dopamine reuptake inhibitor

Novel inhibitor of Pak1 activation, anti-cancer ingredient isolated from the Chinese traditional herb Curcuma wenyujin

The first selective inhibitor of Histone Deacetylase 2 (HDAC2)

Novel antimalarial agent

Elongation factor P (EF-P) fuction modifier

Potent furin inhibitor, blocking furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.

Novel chimeric degrader against cellular retinoic acid binding proteins (CRABPs), inducing the AhR-dependent degradation of CRABP-1 and CRABP-2 via the ubiquitin-proteasome pathway

Novel chimeric degrader against bromodomain-containing (BRD) proteins, inducing the interaction of AhR and BRD proteins and displaying effective anticancer activity that correlated with protein knockdown activity

Cofactor for mitochondrial deacetylase sirtuin-3 enzyme, regulating energy metabolism and immunity and modulating inflammasome assembly

Novel Selective and Orally Active Oxytocin Receptor Antagonist for the Prevention of Preterm Labor

SSR-180,575 is a drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It has been shown to have neuroprotective and cardioprotective effects and to stimulate steroidogenesis of pregnenolone in the brain, which may be linked to its neuroprotective action.

Inhibitor of the replication of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2)

Novel non-peptidic highly potent somatostatin receptor 3 (SSTR3) agonist

Novel potent sstr3 antagonist, showing to reduce glucose excursion in a mouse oGTT assay