Potent, Vascular Endothelial Growth Factor Receptor-​2 (VEGFR-2) Tyrosine Kinase Inhibitor

Activator for Proprietary Gene Therapy Promoter System

Serotonin-norepinephrine reuptake inhibitor (SNRI); Antidepressant

Novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupting Warburg metabolism and inducing context-dependent cytostasis in cancer cells

Antitumor agent

Natural Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels, acting on the channel as either an agonist or antagonist depending on the nature of the electrophysiological stimulation protocol

Natural anti-inflammatory and antioxidant agent, inhibiting both iNOS expression and NO release in the LPS-induced J774.A1 macrophage cell line, enhancing protein expression levels of PARP-1 and p53, and attenuating intracellular ROS and stress (oxidative

Novel blocker of atrial potassium channels

Natural Reversible Plant Growth Inhibitor

Natural insect ryanodine receptor (RyR) antagonist

Apoptosis inducer, inhibiting Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth

Potent inhibitor of acetylcholine transport

Novel anti-vesiculoviral agent, inhibiting transcription initiation of vesiculoviruses

Novel Inhibitor of the Pro-Angiogenic Activity of the Zinc Finger Transcription Factor Vezf1

The first sub-micromolar inhibitor of the VHL-HIF1α interaction

Natural protein kinase C (PKC) activator and HSP90 inhibitor, sensitizing human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn

Clopidogrel analog as an antiplatelet agent

Broad spectrum antibiotic, inhibiting adenylyl cyclase type 5 (AC5) and protecting against chronic coronary artery occlusion (CAO)

Selective long-acting beta2-adrenergic agonist (LABA) with inherent 24-hour activity for once daily treatment of COPD and asthma

Novel antagonist against hypocretin (orexin) receptor 2, significantly preventing acute morphine-conditioned place preference (CPP) and stress-induced reinstatement of extinguished morphine-CPP in mouse models of opioid reward and relapse

Natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro

Natural antimicrobial, antioxidant, and anti-inflammator agent