ATP-sensitive potassium channel opener

Inhibitor of human collagenase-3 (MMP-13)

Potent and selective inhibitor of matrix metalloprotease MMP-13 (Collagenase-3)

Inhibitor of matrix metalloproteinase-1 (MMP-1)

Potent and Selective Inhibitor of the Norepinephrine Transporter

Secreted frizzled-related protein-1 (sFRP-1) modulaitor

Novel inhibitor of The epidermal growth factor receptor (EGFR), decreasing NSCLC cell proliferation and colony formation, by causing G2/M arrest and apoptosis.

Non-peptide GLP-1 receptor agonist, blocking inflammatory nociception by stimulating β-endorphin release from spinal microglia

Novel Inhibitor of PBP2, Showing Potent β-Lactam Enhancer Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones

Highly conserved neuropeptide derived from Chromogranin A (Parathyroid Secretory Protein 1)

Novel very potent and long acting hetrazepinoic PAF-antagonist

Novel inhibitor of type III secretion system ATPase EscN from enteropathogenic Eecherichia coli

Novel fluoroquinolone antibiotic with potent antimicrobial activity, showing the potential to overcome major drug resistance; its antimicrobial activity was less affected by both pump-mediated efflux and QRDR mutations in P. aeruginosa compared with LVX a

Novel Anti-malarial Plasmodium-Selective Proteasome Inhibitor

Dopamine reuptake inhibitor, also having some SERT affinity

B2 bradykinin receptor antagonist

Natural potent antitumoragent, targeting sarco/endoplasmic reticulum calcium-ATPase (SERCA)2

Novel dual inhibitor of histone deacetylase and topoisomerase I

Novel potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR), preventing PI3K signaling and inhibiting the proliferation of transformed cells with oncogenic PI3K mutant

Novel GluN2B-specific NMDAR antagonist, completely preventing the decrease in insulin secretion of about 32 % provoked by a 24-h-treatment with NMDA/glycine, eliminating NMDA-induced changes in the oxidation status of the islet cells and elevating the sen

Potent uncompetitive NMDA receptor antagonist

Unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS)