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Cat. No. Product name CAS No.
DC74001 GE1111

GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM.

DC74002 GMFBI.1

GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.

709608-85-5
DC74003 GNE-1858

GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 with IC50 of 1.9 nM in the SLP76 phosphorylation assay.

2680616-96-8
DC74004 GNF362

GNF362 (GNF-362) is a highly potent, selective inhibitor of inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) with IC50 of 9 nM.

1003019-41-7
DC74005 GNF-9228

GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation.

313234-20-7
DC74006 GO-203

GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling.

1222186-26-6
DC74007 GQ352

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.

DC74008 GSK898

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.

1953156-92-7
DC74009 H3B-616

H3B-616 (H3B 616) is a potent, selective allosteric inhibitor of CPS1 with IC50 of 66 nM, demonstrates no appreciable inhibition of CPS2 (IC50>100 uM).

2468199-06-4
DC74010 HB-MIX1902 Supplement (10X)

HB-MIX1902 Supplement (10X) is an optimized serum-free supplement used to promote and maintain the growth, maturity and viability of iPS-derived hepatic and biliary cells. MIX1902 is provided as a 10X liquid and is intended to be used with Hepatocyte Cult

DC74011 HJ445A

HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM.

DC74012 HP661

HP661 is a potent, and selective oral complex I OXPHOS inhibitor with 76% inhibition at 1u M in H460 cells using electron flow assays, inhibits high-OXPHOS H460 cell viability with IC50 of 5 nM.

2938220-60-9
DC74013 HPK1 PROTAC SS44

HPK1 PROTAC SS44 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1.

2636072-58-5
DC74014 HQY426

HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity.

DC74015 HQY436

HQY436 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.15 uM, exhibits potent antitumor activity.

DC74016 HsClpP activator ZK53

HsClpP activator ZK53 is a potent, selective activator of mitochondrial caseinolytic protease P (HsClpP) with EC50 of 0.22 uM in FI-based protease activity assays, inactive toward bacterial ClpP proteins.

DC74017 HTL0041178

HTL0041178 is a potent GPR52 agonist with EC50 of 27.5 nM (human or rat GPR52).

2642079-89-6
DC74018 HTS13286

HTS13286 is a selective AQP9 inhibitor with IC50 of 1.5 uM (inhibition of CHO-AQP9 cell water permeability).

727359-12-8
DC74019 HYGIC

HYGIC is a small molecule that simultaneously induces hypocotyl elongation and thickening via the ethylene signaling pathway activated by endogenous ethylene.

923742-91-0
DC74020 I194496

I194496 (I 194496) is a novel potent, selective inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 0.79 uM.

445238-07-3
DC74021 IBS007125

IBS007125 is a small molecule inhibitor of c-Maf, inhibits multiple myeloma proliferation by targeting cMaf transcriptional activity.

DC74022 IDE-397

IDE-397 (GSK-4362676, GSK-676) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts.

2439277-80-0
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