Cat. No. | Product name | CAS No. |
DC74156 |
S-181
S-181 (S 181) is a specific small-molecule activator (modulator) of β-glucocerebrosidase (GCase) with AC50 of 1.49 uM and a maximum activation of 780%. |
2270984-21-7 |
DC74157 |
S202
S202 is a potent, selective and brain-penetrant small molecule inhibitor of ceramide galactosyltransferase (CGT) with IC50 of 15 nM in the cell-lysate assays and 3.6 nM in intact-cell assays. |
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DC74158 |
S9-A13
Featured
S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.S9-A13 does not inhibit other members of the SLC26 family and has no effects on Cl− channels such as CFTR, TMEM16A, or VRAC.S9-A13 (0-1 uM ) inhibits SLC26A9 currents in a dose-dependent manner in HEK293 cells, but shows little effects on CFTR currents in HEK293 cells at the highest concentration (5 uM).S9-A13 has a minor effect on ion transport in human airway epithelial cells and mouse trachea, despite clear expression of SLC26A9 in the apical membrane of ciliated cells. |
1223771-84-3 |
DC74159 |
SACLAC
SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines. |
2248703-42-4 |
DC74160 |
SAN4825
SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM. |
158020-72-5 |
DC74161 |
SAR439883
Featured
SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively. |
|
DC74162 |
SB1501
SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo. |
2757411-32-6 |
DC74163 |
SBI-0802936
SBI-0802936 (SBI 0802936) is an analog of SMIP004-7, inhibits NADH:ubiquinone oxidoreductase (complex I), 4-6 times more potently than SMIP004-7, acting in the same uncompetitive fashion as SMIP004-7. |
1946799-48-9 |
DC74164 |
SBL-105
SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH). |
|
DC74165 |
SBT-272
SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function. |
2356106-71-1 |
DC74166 |
SB-U015
SB-U015 is a MitoQ derivative and tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor. |
|
DC74167 |
SC-919
SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively. |
2245949-62-4 |
DC74168 |
Secdin
Secdin is a small-molecule inhibitor of Arabidopsis thaliana ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors (GEFs), impaires both hypocotyl and root growth in young Arabidopsis seedlings with IC50 of 4 uM. |
701231-07-4 |
DC74169 |
Seletracetam
Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy. |
357336-74-4 |
DC74170 |
SFI003
SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM. |
2361332-90-1 |
DC74171 |
SHR170008
SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme. |
|
DC74172 |
SI-2 hydrochloride
A potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. |
|
DC74173 |
Siastatin B
Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases. |
54795-58-3 |
DC74174 |
SJ572946
SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays. |
78584-09-5 |
DC74175 |
SMC-21598
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3. |
3392-07-2 |
DC74176 |
SMIP004-7
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I). |
72072-16-3 |
DC74177 |
SN34960
Featured
SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. |
1567836-70-7 |