Cat. No. | Product name | CAS No. |
DC47887 |
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader. (From patent WO2017180417A1 compound s7). |
1799711-31-1 |
DC47888 |
Thalidomide-O-amido-C6-NH2
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. |
1950635-13-8 |
DC47889 |
Thalidomide-5-NH2-CH2-COOH
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for the treatment of one or more diseases (extracted from patent WO2021170109A1) . |
2412056-27-8 |
DC47900 |
SJ995973
SJ995973 (PROTAC) is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins. |
|
DC47962 |
Lenalidomide-C5-amido-Boc
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC. |
2138441-25-3 |
DC47990 |
Folate-MS432
Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells. |
|
DC48040 |
Biotin-PEG8-Vidarabine
Biotin-PEG8-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
|
DC48041 |
Biotin-PEG7-C2-S-Vidarabine
Biotin-PEG7-C2-S-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
|
DC48042 |
Biotin-PEG7-C2-NH-Vidarabine-S-CH3
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
|
DC48049 |
AU-15330
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity. |
2380274-50-8 |
DC48050 |
ATP-PEG8-Biotin
ATP-PEG8-Biotin is a PEG-based linker that incorporates ATP. ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. |
|
DC48368 |
PROTAC IRAK3 degrade-1
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 (IC50 = 5 nM). |
2712600-00-3 |
DC48369 |
AGB1
Featured
AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ∼13 nM. |
2776190-62-4 |
DC48370 |
MS98
MS98 is a potent and selective PROTAC AKT degrader. MS98 depletes cellular total AKT (T-AKT) with the DC50 value of 78 nM. MS98 binds to AKT1, AKT2, and AKT3 with Kds of 4 nM, 140 nM, and 8.1 nM, respectively. |
2376137-31-2 |
DC48371 |
XY-06-007
XY-06-007 is a selective and potent bump-and-hole (B&H)-PROTAC BRD4BD1L94V degrader. XY-06-007 shows a DC50, 6 h of 10 nM against BRD4BD1L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies. |
|
DC48372 |
MS170
MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively. |
2376136-61-5 |
DC48373 |
dTAGV-1 TFA
Featured
dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. |
2624313-15-9 |
DC48374 |
LCL-ER(dec)
LCL-ER(dec) is a potent and selective oligonucleotide-type degrader via targeting transcription factor (TFs). The main target of LCL-ER(dec) is SNIPER (specific and non-genetic inhibitor of apoptosis protein [IAP]-dependent protein erasers). LCL-ER(dec) selectively degrades ERα (estrogen receptor α) via the UPS (ubiquitin-proteasome system) with an IC50 of 31.2 μM. LCL-ER(dec) is applicable to the development of other oligonucleotide-type degraders that target different TFs. |
|
DC48423 |
Boc-NH-PEG11-OH
Boc-NH-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
1556847-53-0 |
DC48429 |
Di(N-succinimidyl) adipate
Di(N-succinimidyl) adipate (DSAP) is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs. |
59156-70-6 |
DC48432 |
tert-Butyl 11-aminoundecanoate
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker that refers to the PEG composition. tert-Butyl 11-aminoundecanoate is applicable to the synthesis of a series of PROTACs. |
220851-29-6 |
DC48434 |
TD-165
Featured
TD165(TD 165) is a PROTAC-based cereblon (CRBN) degrader that degrads Cav1.2α with the DC50 of 20.4 nM, comprising a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. |
2305936-56-3 |