Cat. No. | Product name | CAS No. |
DC7634 |
PKC-412 (Midostaurin)
Featured
PKC-412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. |
120685-11-2 |
DC7238 |
Gedatolisib(PKI-587)
Featured
PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively. |
1197160-78-3 |
DC5055 |
Plerixafor (AMD3100)
Featured
Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
110078-46-1 |
DC8158 |
Pexidartinib(PLX3397)
Featured
PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS. |
1029044-16-3 |
DC1071 |
Vemurafenib (PLX4032)
Featured
PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. |
918504-65-1 |
DC6301 |
PLX-4720
Featured
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf. |
918505-84-7 |
DC10786 |
PLX51107
Featured
PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation. |
1627929-55-8 |
DC7704 |
Poziotinib
Featured
Poziotinib, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. |
1092364-38-9 |
DC7280 |
Pracinostat(SB939)
Featured
Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I. |
929016-96-6 |
DC9359 |
Pralatrexate
Featured
Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. |
146464-95-1 |
DC9902 |
PRIMA-1
Featured
PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. |
5608-24-2 |
DC10070 |
PRIMA-1MET(APR-246)
Featured
PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity. |
5291-32-7 |
DC10641 |
PRN1371
Featured
PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively. |
1802929-43-6 |
DC10464 |
PT2385
Featured
PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. |
1672665-49-4 |
DC7486 |
PX-478 2HCL
Featured
PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells. |
685898-44-6 |
DC7664 |
Quarfloxin (CX-3543)
Featured
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. |
865311-47-3 |
DC5197 |
Quizartinib (AC220)
Featured
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2. |
950769-58-1 |
DC2068 |
R547
R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively. |
741713-40-6 |
DC5049 |
RAF265 (CHIR-265)
Featured
RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf. |
927880-90-8 |
DC8940 |
Raltitrexed
Featured
Raltitrexed(ZD1694), an inhibitor of thymidylate synthase, is an antimetabolite drug used in cancer chemotherapy. |
112887-68-0 |
DC7808 |
Refametinib (BAY86-9766)
Featured
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. |
923032-37-5 |
DC9777 |
Regorafenib monohydrate(BAY 73-4506)
Featured
Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. |
1019206-88-2 |