Pexidartinib(PLX3397)

  Cat. No.:  DC8158   Featured
Chemical Structure
1029044-16-3
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More than 5000 active chemicals with high quality for research!
Field of application
PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.
Cas No.: 1029044-16-3
Chemical Name: 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
Synonyms: PLX3397; PLX-3397; PLX 3397; CML-261; CML 261; CML261; FP-113; FP 113; FP113; Pexidartinib; Turalio
SMILES: C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F
Formula: C20H15ClF3N5
M.Wt: 417.81
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively.
In Vivo: Pexidartinib is a potent drug for treatment of cancer and used for Phase III TGCT clinical trial[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC8158 Pexidartinib(PLX3397) PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.
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