Pexidartinib(PLX3397)
Cat. No.: DC8158
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Chemical Structure
1029044-16-3
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Field of application
PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS.
| Cas No.: |
1029044-16-3 |
| Chemical Name: |
5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine |
| Synonyms: |
PLX3397; PLX-3397; PLX 3397; CML-261; CML 261; CML261; FP-113; FP 113; FP113; Pexidartinib; Turalio |
| SMILES: |
C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F |
| Formula: |
C20H15ClF3N5 |
| M.Wt: |
417.81 |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively. |
| In Vivo: |
Pexidartinib is a potent drug for treatment of cancer and used for Phase III TGCT clinical trial[1]. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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