Cat. No. | Product name | CAS No. |
DC73174 |
MK256
MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively. |
2271348-04-8 |
DC73175 |
NCGC00131308
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays. |
932546-41-3 |
DC73176 |
NCT02
NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. |
790245-61-3 |
DC73177 |
RGB-286199
RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo. |
784210-85-1 |
DC73178 |
SNX631
SNX631 (SNX-631) is a potent, selective inhibitor of CDK8/19 Mediator kinase with IC50 of 10.3 nM in the NF κB-dependent cell-based assays. |
868066-26-6 |
DC73179 |
SW394703
SW394703 is a novel DDB1-dependent molecular glue degrader for cyclin K, SW394703 is toxic to HCT116 cells (IC50=1.2 uM). |
1357638-86-8 |
DC73180 |
TMX-2039
TMX-2039 is a pan-CDK inhibitor with low nanomolar enzymatic IC50s (0.5-50 nM) for both cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). |
2488892-01-7 |
DC73181 |
XPW1
XPW1 is a potent and selective CDK9 inhibitor with excellent anti-ccRCC activity and low toxicity. |
2700286-66-2 |
DC73182 |
YPN-005
YPN-005 (YPN005) is a highly potent, selective inhibitor of cyclin-dependent kinase 7 (CDK7) with IC50 of 31 nM, with low inhibition for CDK2 and CDK5. |
|
DC73183 |
ZNL-05-044
ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity. ZNL-05-044 treatment leads to G2/M cell cycle arrest, impacts CDK11-dependent mRNA splicing in cells. |
|
DC73184 |
ZSQ836
ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12. |
2634811-35-9 |
DC74624 |
Tibremciclib
Tibremciclib is a CDK4 inhibitor with antineoplastic activity. |
2397678-18-9 |