DMG-PEG2000-NHS is a PEG derivative that can be used in various biomedical applications, such as the construction of drug delivery systems (siRNA delivery liposomes, lipid nanoparticle, etc.). The active ester (NHS) can react with an amino group (-NH2) to form a stable amide bond, which can be used as a linker in a bioconjugation strategy to modify amino-linked peptide proteins as well as other small molecules.

DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents. DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4 It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.

Compound A-11 (Lipid A11) is a novel ionizable cationic lipid for used for tLNP(targeting antibody LNP) targeting to T cell,with pKa range 6-7, high encapsulation efficiency and high T cell transfection, compared to benchmark ATX-126 and other lipids.

Cis-AGB1 is a negative control for AGB1 . Exhibits no significant VHL binding affinity.

Compound 3 (AKT1/E17K inhibitor) is an allosteric, lysine-targeted salicylaldehyde, AKT1 (E17K) inhibitors with IC50 of 0.6 nM and shows 28-fold and 103-fold selectivity over AKT1 (WT) and AKT2 (WT), respectively.

MS105 is a potent PTK6 PROTAC degrader. MS105 effectively reduces PTK6 protein levels, induces apoptosis, and inhibits growth and migration of breast cancer cell lines of diverse subtypes.

ACR-2316 is a potentially first-in-class, potent, selective WEE1/PKMYT1 inhibitor with IC50 of 2 nM/44 nM. ACR-2316 demonstrates greater potency in all cell lines tested compared to adavosertib and lunresertib.

ZZ3 is a potent CDK12/13 molecular glue degrader with DC50 of 35 nM and 57 nM, respectively.