Cat. No. | Product name | CAS No. |
DC73520 |
KME-2780
KME-2780 (KME2780) is a potent and selective dual IRAK1 and IRAK4 (IRAK1/4) inhibitor with IC50 of 19 and 0.5 nM, respectively. |
2968466-26-2 |
DC73521 |
KME-3859
KME-3859 is a potent, selective IRAK4 inhibitor with IC50 of 5 nM, 100-fold selective over IRAK1. |
2968466-04-6 |
DC73522 |
TJ-M2010-2
TJ-M2010-2 is a small molecule inhibitor of MyD88 homodimerization, interacts with MyD88 TIR domain. |
1333465-88-5 |
DC73523 |
PCC-0105002
PCC-0105002 is a novel small molecule inhibitor of PSD95-nNOS protein-protein interaction with IC50 of 1.4 uM. |
|
DC73524 |
T1059
T1059 is a selective inhibitor of eNOS/iNOS with a long-term vasoconstrictive effect in vivo. |
1786406-98-1 |
DC73525 |
ADS032
ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin-induced NLRP3-induced IL-1β secretion from LPS-primed iBMDMs with IC50 of 30 uM. |
2757333-37-0 |
DC73526 |
DFV890
Featured
DFV890 (IFM-2427) is apotent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation,prevents NLRP3 inflammasome assembly in response to sterile danger signals. |
2271394-34-2 |
DC73527 |
FK 156
FK156 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
76490-22-7 |
DC73528 |
FK 565
FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
79335-75-4 |
DC73529 |
JC2-11
JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes. |
937820-89-8 |
DC73530 |
JT001
JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly. |
|
DC73531 |
JT002
JT002 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 6 nM (IL-1β production from hPBMCs), inhibits NLRP3 mediated cytokine production and pyroptosis. |
2238820-43-2 |
DC73532 |
ML146
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells. |
1164540-96-8 |
DC73533 |
NDT-19795
NDT-19795 is the carboxylic acid metabolite of selective NLRP3 inhibitor NT-0796, suppresses release of IL-1β in LPS-activated human PBMCs with IC50 of 47 nM. |
2272917-12-9 |
DC73534 |
NIC7
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
1019134-09-8 |
DC73535 |
NP3-146
NP3-146 is a small molecule NLRP3 inflammasome inhibitor and an analog of MCC950. |
210826-47-4 |
DC73536 |
ZYIL1
ZYIL1 is an oral small molecule NLRP3 inflammasome inhibitor, exhibits potent (IC50 in nanomolar range) in human whole blood and supresses inflammation caused by the NLRP3 inflammasome. |
2455519-86-3 |
DC73537 |
BMS135
BMS135 is a small molecule h-PD1/h-PD-L1 interaction inhibitor with IC50 of 79.1 nM, bind specifically to hPD-L1 through a unique mode of action, induces the dimerization of hPD-L1. |
1675202-86-4 |
DC73538 |
BMS136
BMS136 is a small molecule h-PD1/h-PD-L1 interaction inhibitor with IC50 of 96.7 nM, bind specifically to hPD-L1 through a unique mode of action, induces the dimerization of hPD-L1. |
1675203-24-3 |
DC73539 |
IMMH-010
IMMH-010 (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays. |
2158336-02-6 |
DC73540 |
IMMH-010 maleate
IMMH-010 maleate (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays. |
2541982-47-0 |
DC73541 |
MAX10181
MAX10181 (MAX-10181) is an orally active small molecule PD-L1 inhibitor, shows similar efficacy as Durvalumab in the head to head test of human PD-L1 knock-in MC38 cell line in human PD-1 knock-in mice. |
2171558-14-6 |