Home > Inhibitors & Agonists
Cat. No. Product name CAS No.
DCC5597 Zbh-1205

Novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than CPT-11 and SN38 at inhibiting topoismerase-1

DCC5598 Zd1611

Endothelin Receptor Antagonist

186497-38-1
DCC5599 Zd2138

Potent, orally active inhibitor of 5-lipoxygenase (5-LO)

140841-32-3
DCC5600 Zd6126

Vascular targeting agent (VTA)

219923-05-4
DCC5601 zd6169

Potassium channel opener

147696-46-6
DCC5602 Zdhhc Substrate Peptide

ZDHHC (zinc finger Asp-His-His-Cys) substrate peptide, a 15-mer peptide sequence from KRas4a plus two tryptophan residues

DCC5603 Zdlt-1

Novel potent HDAC inhibitor with IC50 values for class I HDACs 1, 2, and 3 below 4 nM, and IC50 for HDAC6 at 6 nM.

DCC5604 Z-don-val-pro-leu-ome

Site specific inhibitor of tissue transglutaminase

DCC5605 Zdwx-25

Novel daul inhibitor of GSK-3β (IC 50 = 71 nM) and DYRK1A (IC 50 = 103 nM) with good blood-brain barrier penetrability, inhibiting hyperphosphorylation of tau protein in okadaic acid (OKA)-induced SH-SY5Y cells

DCC5606 Zfh7116

Novel inhibitor of pro-HGF activation

DCC5607 Zg-2033

Novel Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist

DCC5608 Z-ggr-amc

Fluorogenic peptide substrate for a direct fluorometric assay of urokinase, tissue-type plasminogen activator, trypsin and thrombin

66216-78-2
DCC5609 Ziconotide

Atypical analgesic agent for the amelioration of severe and chronic pain

107452-89-1
DCC5610 Zilpaterol

Growth promotant, acting as a ß-AR (ß-Adrenergic) agonist

119520-05-7
DCC5611 Zinc00723145

The first nonpeptidic inhibitor of ovarian cancer cells growth targeting human thymidylate synthase (hTS)

352348-99-3
DCC5612 Zinc01765622

Novel antagonist for mLST8

61601-94-3
DCC5613 Zinc03838680

Potent VEGFR-2 inhibitor

DCC5614 Zinc04085549

Novel blocker of AKT1-FAK interaction, reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylation

383147-88-4
DCC5615 Zinc04177596

Novel Nef Protein Inhibitor; Anti-HIV

364052-84-6
DCC5616 Zinc04502991

Novel TNF-α inhibitor

878427-47-5
DCC5617 Zinc04515726

Novel effective immune checkpoint inhibitor (ICI) against the suppression of T-cell activation, proliferation, and tumor cell eradication.

DCC5618 Zinc04574788

Novel potent small molecule lligand of miR-21, binding to the major groove of miR-21 hairpin conformation

DCC5619 Zinc05848961

Novel TNF-α inhibitor

DCC5620 Zinc06472206

Potent and selective agonist of peroxisome proliferator activated receptors-α (PPAR-α)

313962-58-2
DCC5621 Zinc08438472

Potent and selective agonist of peroxisome proliferator activated receptors-α (PPAR-α)

443872-20-6
DCC5622 Zinc08790006

Novel SIRT1 inhibitor

864751-93-9
DCC5623 Zinc08792229

Novel SIRT1 inhibitor

904514-73-4
DCC5624 Zinc08792355

Novel SIRT1 inhibitor

904513-52-6
DCC5625 Zinc08985213

Novel effective immune check point inhibitor (ICI) against the suppression of T-cell activation, proliferation, and tumor cell eradication.

DCC5626 Zinc09410451

Potent Ebolavirus (EBOV) Inhibitor

1093065-66-7
DCC5627 Zinc12909780

Novel dose-dependent inhibitor of TNF-α-induced NF-κB activation

DCC5628 Zinc17043486

Novel CDK6 inhibitor

DCC5629 Zinc17167211

Potent and selective agonist of peroxisome proliferator activated receptors-α (PPAR-α)

592539-21-4
DCC5630 Zinc20531199

Novel EGFR triple mutant T790M/C797S allosteric inhibitor

DCC5631 Zinc27905174

Novel GDNF Family Receptor Agonist

DCC5632 Zinc32540717

Potent Ebolavirus (EBOV) Inhibitor

1010869-76-7
DCC5633 Zinc36617540

Novel Nef Protein Inhibitor; Anti-HIV

1174905-91-9
DCC5634 Zinc4085554

Novel blocker of AKT1-FAK interaction, reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylation

383147-92-0
DCC5635 Zinc50166190

Novel Zika virus RNA polymerase inhibitor

1455388-54-1
DCC5636 Zinc63908257

Novel CtpF inhibitor, inhibiting Ca -dependent ATPase activity in Mtb membrane vesicles

DCC5637 Zinc64700951

Novel gp120 of HIV-1 Antagonist

DCC5638 Zinc65022200

Novel potent and specific inhibitor of the UNC119-Src interaction, binding to UNC119 in cells, and inducing redistribution of Src to endomembranes and reduction of activating Src autophosphorylation on Y419

DCC5639 Zinc69811181

Novel ASCT2 inhibitor

DCC5640 Zinpyr-1

Cell-permeable fluorometric zinc sensor

288574-78-7
DCC5641 Zk187638

Non-competitive AMPA receptor antagonist

397298-63-4
DCC5642 Zk230211

Type III progesterone receptor antagonist with enhanced antiproliferative properties

211254-73-8
DCC5643 Zk-304709

Novel oral multitarget tumour growth inhibitor

1010440-84-2
DCC5644 Zk-806450

Novel potent inhibitor of factor Xa (FXa)

DCC5645 Zl006-05

Novel dual mordulator of nNOS-PSD-95 interaction and GABA A receptor

DCC5646 Zl0513

Novel potent and selective BRD4 bromodomain 1 (BD1) inhibitor

2230496-92-9
DCC5647 Zl0516

Novel potent and selective BRD4 bromodomain 1 (BD1) inhibitor

2230496-93-0
DCC5648 Zl3138

Novel β-catenin/B-cell lymphoma 9 (BCL9) inhibitor, disrupting the β-catenin/BCL9 protein-protein interaction (PPI) with a Ki of 0.96 μM and without affecting the β-catenin/E-cadherin interaction in living cells, displaying good selectivity for β-catenin/

DCC5649 Zld10a

Novel potent and highly selective inhibitor of wild-type and mutant versions of EZH2

1782064-91-8
DCC5650 Zm-181037

ATP-sensitive potassium channel-blocker; Eukalemic diuretic

138779-29-0
DCC5651 zm-189154

Non-steroidal pure antioestrogen

101908-22-9
DCC5652 zm-230487

5-Lipoxygenase (5-LO) inhibitor

155944-23-3
DCC5653 Zm-244085

K-Channel opener (PCO) activating predominantly KATP channels in vitro to relax bladder detrusors

149398-59-4
DCC5654 zm-253270

Selective nonpeptide, NK-2 receptor (NK-2R) antagonist

169340-04-9
DCC5655 Zm-260384

Potassium channel opener

161229-62-5
DCC5656 Zm39923 Hydrochloride

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3)

58753-54-1
DCC5657 Zn-htsm

Novel antidiabetic agent for the treatment of type 2 diabetes mellitus (DM)

DCC5658 Zofenoprilat

Inducer of functional angiogenesis through increased H 2 S availability

75176-37-3
DCC5659 Zolantidine Dimaleate

Potent, selective, and brain penetrating H2 receptor antagonist

104076-39-3
DCC5660 Zoledronate Disodium

Inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma

131654-46-1
DCC5661 Zolimidine

Gastroprotective agent for the treatment of peptic ulcer

1222-57-7
DCC5662 Zp1-12cl

Novel zinc sensor with a chloroalkane linker, reacting specifically with the engineered protein HaloTag, binding zinc ions with a threefold fluorescence enhancement

DCC5663 Ztb23(r)

The first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

306324-21-0
DCC5664 Ztz240

Novel potentiator of KCNQ2 potassium channels

325457-98-5
DCC5665 Zu-4280011

Novel COX-2 inhibitor

1001770-63-3
DCC5666 Zuclopenthixol Dihydrochloride

Antagonist of D1 and D2 dopamine receptors.

58045-23-1
DCC5667 Z-wehd-fmk

Potent, cell-permeable and irreversible caspase-1/5 inhibitor

210345-00-9
DCC5668 Zwittermicin A

Natural antibiotic, having diverse biological activities including broad-spectrum antibiosis against Bacteria and lower Eukarya, plant disease suppression, and enhancement of the insecticidal activity of Bacillus thuringiensis toxin against lepidopteran l

155547-95-8
DCC5669 Zwm026

Novel multi-target inhibitor, harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR

DCC5670 Zxh-1-161 Featured

Novel Selective Degrader of GSPT1

2407654-51-5
DCC5671 Zx-j-19j

Novel inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrating remarkable inhibition of tumor cell growth, comparable to CsA but much stronger than 5-fluorouracil

1352576-02-3
DCC5672 Zx-j-19l

Novel inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrating remarkable inhibition of tumor cell growth, comparable to CsA but much stronger than 5-fluorouracil

1346754-06-0
DCC5673 Zxx2-77

Cyclooxygenase-1 inhibitor

304913-22-2
DCC5674 Zydpla1

Novel next generation orally active DPP-4 inhibitor to treat Type 2 Diabetes

1263402-76-1
DCC5675 Zyj-25e

Novel histone deacetylase inhibitor (HDACi) with potent oral antitumor activities

1287261-04-4
DCC5676 Zyj-34c

Novel histone deacetylase inhibitor (HDACi) with potent oral antitumor activities

1314556-93-8
DCC5677 Zyj-34v

Oral active histone deacetylase inhibitor with potent antitumor activity

1450662-32-4
DCC5678 Zyz-803

Novel slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure

2088043-51-8
DC65717 DPPE Featured

DPPE is a derivative of phosphatidylethanolamine with (16:0) palmitoyl acyl chains

923-61-5
DC65720 Bis(linoleyl) ketone Featured

1169768-30-2
DC65721 1,2(R)-Dioleyloxy-sn-giycero-3-phosphocholine Featured

145849-25-7
DC65722 1,2-Dioleyloxy-sn-giycero-3-phosphocholine Featured

1068-79-0
DC65723 1-Palmitoyl-sn-glycero-3-phosphocholine Featured

1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant gonadal LPC (lysophosphatidylcholine).

17364-16-8
DC65725 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC Featured

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.

26853-31-6
DC65726 DPPE-cap-Biotine Featured

384835-52-3
DC65727 DMPG Featured

DMPG is a phospholipid containing the saturated long-chain (14:0) myristic acid.

200880-40-6
DC65728 DSPA Featured

DSPA is a form of phosphatidic acid (PA) containing a phosphatidic acid head group and 18:0 fatty acids

108321-18-2
DC65729 DOPG-Na Featured

DOPG-Na is a phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other artificial membranes. DOPG is an anionic phospholipid derivative. The negatively charged liposomes prepared with DOPG has been found to possess the best loading capacity and encapsulation rate for Peptide Nucleic Acid (PNA) oligomers.

67254-28-8
DC65730 DPhPC Featured

DPhPC is a phospholipid used to synthesize bilayer vesicles. DPhPC bilayers do not permit ions to leak in the absence of a pore/ion channel, which can be used for studies on channel proteins.

207131-40-6
DC65731 DPPA Featured

DPPA is a form of phosphatidic acid (PA).

169051-60-9
DC65739 18:0-18:2 PE Featured

18:0-18:2 PE is a lipid for agents delivering. 18:0-18:2 PE is mainly composed of unsaturated fatty acids. 18:0-18:2 is considered important precursors of important odorants (IOs) in Eriocheir sinensis.

7266-53-7
DC65742 (s)-1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Featured

71357-99-8
DC65745 POPE Featured

POPE is a phospholipid, and can be used for drug delivery.

26662-94-2
DC65753 DOTAP Mesylate Featured

DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

252769-92-9
DC65754 DSG Featured

1429-59-0
DC65757 AOP Featured

156311-85-2
DC65758 Methoxypoly(ethylene glycol)propionitrile(mPEG-CN) Featured

DC65759 Methoxypoly(ethylene glycol)Giycerol(mPEG-GLC) Featured

DC65760 Methoxypoly(ethylene glycol)Epoxide(mPEG-epoxide) Featured

DC65761 DMG-mPEG2000(酯型) Featured

DC65762 Polyethylene glycol[PEG]dimyristoyl glycerol Epoxide Featured

DC65763 MPEG-GLC Featured

DC65765 mPEG2000-CH2CH2CN Featured

DC65766 mPEG2000-NPC Featured

DC65770 DMPE-mPEG2000(NA盐) Featured

384835-59-0
DC65771 DMG-mPEG5000 Featured

DC65777 DLPA Featured

DLPA is a phosphatidic acid (PA) containing the medium-chain (12:0) lauric acid.

108321-06-8
DC65778 PLinPE Featured

26662-95-3
DC65779 PLPA Featured

322647-59-6
DC65780 DLPE Featured

DLPE is a derivative of phosphatidylethanolamine with lauric acid (12:0) acyl chains.

59752-57-7
DC65781 DPyPE Featured

DPyPE is a phosphatidylethanolamine lipid composed of polyisoprene alkyl chains. DPyPE is a co-lipid forvaxfectin mixed with GAP-DMORIE in a 1:1 ratio.

201036-16-0
DC65784 SOPA-NA Featured

384833-24-3
DC65785 18:0 Diether PC Featured

1188-85-8
DC65786 mPEG2000-DSPE Featured

mPEG2000-DSPE is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.

247925-28-6
DC65787 DOP-DEDA Featured

2247753-10-0
DC65788 DHSM Featured

54353-31-0
DC65791 DPPG sodium Featured

DPPG sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

67232-81-9
DC65796 Tritridecanoin Standard Featured

26536-12-9
DC65797 Diheptanoyllecithin Featured

Diheptanoyllecithin is a non-hydrolyzable analog.

39036-04-9
DC60546 514O6,10 Featured

514O6,10 is an ionizable lipidoid. 514O6,10 formulated LNPs facilitate mRNA delivery to the pancreas.

DC60554 Lipid 20b Featured

Lipid 20b is an ionizable lipid containing a thiophene moiety (Thio-lipid) for mRNA delivery. Lipid 20b enables LNPs to transfect the liver and spleen. Lipid 20b is potent in mRNA delivery to the retina with no acute toxicity.

DC60555 C14-O2 Featured

C14-O2 is an oxidized lipid for mRNA delivery. C14-O2-LNP is capable of potent and selective delivery of mRNA to blood monocytes. C14-O2 LNP is used to deliver a functional CD19-CAR mRNA and is shown to engineer functional CAR monocytes directly in situ.

2639634-77-6
DC60556 Lipid 29d Featured

Lipid 29d is an ionizable lipid containing a thiophene moiety (Thio-lipid) for mRNA delivery. Lipid 29d enables LNPs to transfect the lung and spleen.

DC65849 A1-28 Featured

A1-28 is a disulfide bond-containing ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.

DC65850 VL422 Featured

VL422 is an ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.

2765519-47-7
DC65851 CL15F6 Featured

CL15F6 is an ionizable cationic lipid (pKa = 6.75).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA and polymer-lipid hybrid nanoparticles for the delivery of plasmid DNA in vitro.1,2

2766493-40-5
DC65852 C3-K2-E14 Featured

C3-K2-E14 is an ionizable cationic lipid (pKa = 5.5).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA or siRNA in vitro and in vivo. LNPs containing C3-K2-E14 and encapsulating siRNA targeting the gene encoding colony-stimulating factor 1 (Csf1) reduce the percentage of circulating Ly6Chi monocytes and increase the percentage of circulating Ly6Cint monocytes in mice.

2933215-86-0
DC65853 (S)-C12-200 Featured

(S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200 (Item No. 36699).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intravenous administration of LNPs containing (S)-C12-200 and encapsulating mRNA encoding Cre recombinase increase the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice greater than (R)-C12-200-containing and Cre mRNA-encapsulating LNPs.

1226552-44-8
DC65854 PPPDA-O16B Featured

PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.1 LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.

DC65856 Lipid C3 Featured

Lipid C3 is an ionizable cationic lipid (pKa = 5.05-5.671).1,2 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating mRNA encoding α-L-iduronidase (Idua) to neonates increase midbrain and hippocampal α-L-iduronidase enzyme activity and decrease forebrain, midbrain, and hippocampal glycosaminoglycan levels in an Idua-W392X mouse model of the lysosomal storage disorder mucopolysaccharidosis type I, also known as Hurler syndrome. Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating an mRNA reporter to fetal macaques in utero increase brain GFP expression.

2639634-93-6
DC65857 BAmP-O16B Featured

BAmP-O16B is an ionizable cationic amino lipid that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing BAmP-O16B and encapsulating NSA-inactivated RNase A reduce the viability of SiHa and HeLa cancer cells, but not non-cancerous NIH3T3 and HEK293T cells, upon intracellular reactivation of RNase A by glutathione (GSH).

DC65858 Lipid OA2 (hydrochloride) Featured

Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA.1 LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.

DC72914 UE2343

UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.

1346013-80-6
DC72915 AM4085

AM4085 is a potent, orally bioavailable lectin domain of FmLH antagonist with IC50 of 0.19 uM.

DC72916 BB2-50F

BB2-50F is a bactericidal inhibitor of M. tuberculosis with MIC value of 8 uM (H37Rv), inhibits succinate dehydrogenase and the F1Fo-ATP synthase.

2226086-65-1
DC72917 BDM71339

BDM71339 is the first small molecule inhibitor of mycobacterial transcriptional regulator EthR, boosts ten times the activity of ethionamide in TB-infected macrophages at low nanomolar concentrations (EC50=72 nM) in vitro.

2580938-64-1
DC72918 BDM88855 hydrochloride

BDM88855 Hcl is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.

2892824-26-7
DC72919 BDM91288

BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiate the activity of a panel of antibiotics against K. pneumoniae.

2892824-53-0
DC72920 BFA1

BFA1 is a specific small-molecule activator of Burkholderia FixLJ signaling pathway, inhibit the virulence of multiple pathogenic Burkholderia species.

263563-30-0
DC72921 COE2-2hexyl

COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL.

2376953-07-8
DC72922 Cresomycin

Cresomycin (CRM) is a bridged macrobicyclic antibiotic via inhibiting bacterial ribosome, shows broad efficacy of CRM against clinical isolates of MDR Gram-negative pathogens differentiates the synthetic macrobicyclic class from traditional lincosamides.

2999743-51-8
DC72923 CUO246

CUO246 (CUO-246) is a potent, selective bacterial DNA gyrase/topoisomerase IV inhibitor, CUO246 is active in vitro against a broad range of Gram-positive, fastidious Gram-negative, and atypical bacterial pathogens.

2250037-27-3
DC72924 D66

D66 is a specific small molecule that disrupts S. Typhimurium membrane voltage without cell lysis, prevents S. Typhimurium survival in macrophages (IC50=6.0 uM) and inhibits bacterial growth under conditions that compromise the cell envelope.

651005-35-5
DC72925 DS01750413

DS01750413 is a novel FtsZ inhibitor and new derivative of PC190723 (Cat. PC-47012), inhibits S. aureus FtsZ protein with IC50 of 2 mg/L, has an IC50 of 0.03 mg/L in cell elongation assay of B. subtilis.

2881067-92-9
DC72926 EPM35

EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.

651006-73-4
DC72927 GSK030

GSK030 (GSK3212030A) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites.

1954699-40-1
DC72928 GSK147

GSK147 (GSK-147) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=40 nM).

DC72929 GSK692

GSK692 (GSK-692) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=10 nM).

2095562-44-8
DC72930 HR3744

HR3744 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 10 uM in saeP1 promoter assays, reduces expression of hla and other virulence factors.

359614-79-2
DC72931 HSGN-189

HSGN-189 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor, exhibits potent antibacterial activity against both MRSA and VRE strains with MICs of 1 ug/mL.

2378181-36-1
DC72932 IITR06144

IITR06144 is a novel nitrofuran and exhibits broad-spectrum bactericidal activity against most MDR bacteria (MIC, 0.5 mg/mL).

89076-51-7
DC72933 JBD1

JBD1 is a small molecule compound that strongly inhibits biofilm formation of S. aureus, including methicillin-resistant strains, induces biofilm inhibition and metabolic remodeling through respiratory activation.

577981-37-4
DC72934 JMV-7061

JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM).

2419903-20-9
DC72935 JSF-2414 Featured

JSF-2414 (JSF2414) is a potent, small molecule GyrB/ParE dual binding inhibitor, simultaneously binds to ATP binding regions of DNA gyrase (GyrB) and topoisomerase (ParE) and displays potent in vitro activity against strains of MRSA, VRSA and VISA.

1673581-19-5
DC72936 JSF-2659

JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 1 g/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced co

DC72937 JSF-3269

JSF-3269 is a small molecule antibacterial inhibitor against Enterococcus faecium with MIC of 1.9-3.8 uM and minimal bactericidal concentration (MBC) of 7.7-15 uM.

DC72938 JSF-3285

JSF-3285 (JSF3285) is a potent small molecule inhibitor of the M. tuberculosis β-ketoacyl synthase KasA with Kd of 70.7 nM in MST assays, shows activity against H37Rv strain with MIC 0.2 uM.

DC72939 KKL-55

KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.

639048-45-6
DC72940 KSK67

KSK67 is a potent small molecule inhibitor of bacterial transcriptional activator PrfA with IC50 of 67 nM, reduces virulence factor expression in L. monocytogene.

1638100-60-3
DC72941 LPC-233

LPC-233 (LPC233) is a highly potent and specific inhibitor of UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC (Ki=8.9 pM), specifically inhibits lipid A synthesis and displays outstanding antibiotic activities.

2142075-09-8
DC72942 MD-124

MD-124 is a potent antibiotic adjuvant against Gram-negative bacteria, sensitizes various Gram-negative bacterial species and strains, including multidrug resistant pathogens, toward existing antibiotics.

2402826-89-3
DC72943 MMV1091186

MMV1091186 (MMV 1091186) is an antimalarial compound that inhibit P. falciparum cytoplasmic isoleucyl tRNA synthetase (cIRS) with IC50 of 0.87 uM.

1043049-81-5
DC72944 MMV652103

MMV652103 is an antimalarial imidazopyridazine compound, exerts potent and selective cytotoxicity in ER+ breast cancer cells, potently inhibits the oncogenic PI4KB and PIK3C2G lipid kinases with IC50 of 1.7 and 0.085 uM, respectively.

1580453-63-9
DC72945 MSU-43085

MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.

2810846-51-4
DC72946 ND-011992

ND-011992 is a cytochrome bd oxidase (Cyt-bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.

2446880-46-0
DC72947 NSC116565

NSC116565 is a potent, time-dependent inhibitor of Mycobacterium tuberculosis (M.tb) ketol-acid reductoisomerase (KARI) with Ki of 95.4 nM.

18903-23-6
DC72948 NTB-3119

NTB-3119 (NTB3119) is a novel benzothiopyranone derivative and anti-tuberculosis agent with potent in vitro activity against both drug-susceptible and drug-resistant tuberculosis clinical strains.

2252473-48-4
DC72949 OTB-658

OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.

2245791-50-6
DC72950 PKZ18-22

PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.

361366-77-0
DC72951 SAV13

SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.

423748-49-6
DC72952 Savirin

Savirin (S. aureus virulence inhibitor) is a small molecule inhibitor inhibiting agr quorum sensing in S. aureus by blocking the transcriptional function of AgrA.

2163006-04-8
DC72953 SF235

SF235 is a small-molecule inhibitor of macrophage infectivity potentiator (Mip) protein with IC50 and Ki 0.42 and 0.29 uM against B. pseudomallei Mip (BpMip) peptidyl-prolyl cis/trans isomerase (PPIase) activity, reduce B. pseudomallei virulence in vitro.

2010156-60-0
DC72954 SK-017154-O

SK-017154-O is a specific and noncompetitive inhibitor of PelA, specifically inhibits PelA esterase activity with IC50 of 11 uM, inhibits Pel-dependent PA14 biofilms with IC50 of 1.8 uM.

133978-91-3
DC72955 SMARt751

SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo.

1616370-52-5
DC72956 SMT-738

SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.

2862851-15-6
DC72957 TBAJ-5307

TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively.

2583850-72-8
DC72958 TBI-166

TBI-166 is a potential next-generation antituberculosis riminophenazine with activity against Mycobacterium tuberculosis (0.063  μg/ml).

2377282-66-9
DC72959 TPP8

TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM.

1581683-17-1
DC72960 TXA707

TXA707 is the active metabolite of TXA709 and bacterial protein FtsZ inhibitor, maintains potent activity against S. aureus strains (e.g., MRSA, VRSA, DNSSA, and LNSSA) that are resistant to current SOC antibiotics.

1609670-89-4
DC72961 TXA709

TXA709 is a prodrug of FtsZ-targeting benzamide compound (TXA707) with enhanced metabolic stability, demonstrates improved pharmacokinetic properties, and superior in vivo antistaphylococcal efficacy (both oral and intravenous) relative to previously iden

1609670-80-5
DC72962 TXY436

TXY436 is an N-Mannich base derivative and FtsZ-directed prodrug of PC190723, TXY436 is effective against S. aureus can also target Gram-negative bacteria, such as Escherichia coli.

1459695-13-6
DC72963 TXY541

TXY541 is a 1-methylpiperidine-4-carboxamide prodrug of PC190723 and bacterial protein FtsZ inhibitor, TXY541 is efficacious in vivo in mouse models of systemic infection with both methicillin-sensitive and methicillin-resistant S. aureus.

1499168-63-6
DC72964 VU0026921

VU0026921 is a small molecule modulator of metal homeostasis in gram-positive pathogens, disrupts metal homeostasis in multiple Gram-positive bacteria, leading to increased reactive oxygen species and cell death.

301321-65-3
DC72965 NPP-669

NPP-669 (NPP669) is an orally bioavailable cidofovir (CDV) analogue and prodrug, has increased lipophilicity, improved oral absorption, reduced nephrotoxicity, increased cellular uptake, and increased activity against several dsDNA viruses compared to CDV

2407828-99-1
DC72966 AG-7404

AG-7404 (AG7404) is a potent, irreversible inhibitor of picornaviral 3C protease, exhibits EC50 values of 80-674 nM against a large panel of programmatically important poliovirus strains.

343565-99-1
DC72967 SJW-2C-227

SJW-2C-227 is a broad-spectrum anti-viral compound that target enterovirus 2C potein, inhibits 2C ATPase activity, exhibits anti-viral activity of SJW-2C-227 with an EC50 of 1.7 µM against EVA71 and 0.52 µM against EV-D68.

693821-95-3
DC72968 ZHSI-1

ZHSI-1 is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.

2925912-67-8
DC72969 ZHSI-1 hydrochloride

ZHSI-1 hydrochloride is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.

DC72970 Cotransin CT8 Featured

Cotransin CT8 (CT-08) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.

1000770-96-6
DC72971 Cotransin CT9

Cotransin CT9 (CT-09) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.

438239-90-8
DC72972 PS3061

PS3061 (PS 3061) is a substrate-selective co-translational translocation inhibitor, modulates SEC61 translocon and inhibits both DENV and ZIKV virion production and replication.

2377739-98-3
DC72973 CWHM-974

CWHM-974 is a fluphenazine derivative with antifungal activity against Candida albicans, significantly reduces susceptibility to multidrug transporter-mediated resistance.

DC72974 FC12406

FC12406 is a highly potent and broadly active antifungal agent, has MIC of 0.2 ug/mL against Candida albicans.

2891868-69-0
DC72975 MMV688766

MMV688766 (MMV 688766) is a small molecule displaying broad-spectrum fungicidal activity through perturbation of lipid homeostasis, inhibits the growth of four geographically distinct C. auris clades with MIC80 of 12.5-50 uM.

904508-14-1
DC72976 NP-BTA

NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.

544420-99-7
DC72977 NPD6433

NPD6433 is a novel broad-spectrum antifungal agent with MIC <10 ug/mL against C. albicans, Candida glabrata, Candida auris, and C. neoformans, inhibits Fas1 enoyl reductase activity.

895908-81-3
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