Novel inhibitor of against human liver FBPase (IC50, 0.029±0.006 μM) and high selectivity relative to the other six AMP-binding enzymes, producing significant glucose-lowering effects on both type 2 diabetic KKAy mice and ZDF rats

Novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein

Novel potent inhibitor of CpFIKK catalytic activity

Novel selective inhibitor of the CREB binding protein (CBP)

Unique inhibitor of MDM2, inhibiting MDM2-p53 interaction and promoting MDM2 degradation

Novel CpIMPDH inhibitor

Novel selective NADPH oxidase 2 (Nox2) inhibitor, attenuating endothelial cell inflammation and vessel dysfunction and restoring mouse hind-limb flow

Novel selective NADPH oxidase 2 (Nox2) inhibitor, attenuating endothelial cell inflammation and vessel dysfunction and restoring mouse hind-limb flow

Novel positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGlu5)

Novel inhibitor of death-associated protein kinase 1 (DAPK1), also inhibiting VEGF-receptor 2 and tyrosine-protein kinase SRC

Novel endothelin receptor antagonist, suppressing the upregulation of matrix metalloproteinases and connexin 43 in hyperthyroid myocardium

Novel potent and selective fluorescent inhibitor of glutaminase (GLS1)

Liposomal-encapsulated combination of daunorubicin and cytarabine for the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs)

Novel RORγt inhibitor, suppressing Th17 cell differentiation, reducing the severity of experimental autoimmune disease models such as EAU, EAE, and type 1 diabetes

Novel RORγt inhibitor, suppressing Th17 cell differentiation, reducing the severity of experimental autoimmune disease models such as EAU, EAE, and type 1 diabetes

Novel NIR-II probe, noninvasively and dynamically visualizing and monitoring many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial th

Novel potent HDAC8 inhibitor

Novel probe for selectively detecting sAβ species in Alzheimer's disease (AD)

Foster Resonance Energy Transfer (FRET) pair for Aβ40 aggregates

Substrate for the assay of creatine kinase, providing a quick source of energy for muscle fibers to contract when they need an initial burst of energy

Novel potent and cell-permeable inhibitor of cAMP-response element binding protein (CREB)

Novel CREBBP Bromodomain Inhibitor