Natural antiangiogenic homoisoflavanone, inhibiting the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells

Antineoplastic and Antibacterial; Inducer of death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism; Dark blue cancer cell growth inhibitor

Selective dopaminergic reuptake inhibitor

Novel potent, selective, and reversible inhibitor of human monoamine oxidase B (hMAO-B)

Novel potent, selective, and reversible inhibitor of human monoamine oxidase B (hMAO-B)

Novel potent and mycobacteria-specific antimycobacterial agent, targeting MmpL3, improving the antimycobacterial activity and being also potent against Mtb

Novel potent and mycobacteria-specific antimycobacterial agent, targeting MmpL3, a mycobacterial mycolic acid transporterr, demonstrating MIC = 0.03, 2, and ≤ 0.12 μg/mL against Mabs, Mycobacterium avium complex (MAC), and Mtb respectively

Potent and selective inhibitor of AKR1C3

Potent and selective inhibitor of AKR1C3

Potent and selective CRTH2 antagonist

TLR4 antagonist, protecting against advanced diabetic nephropathy

Novel potent powerful lipid A analogue as a conjugation-ready TLR4 ligand

Novel TRPM8 agonist

Novel water-soluble, potent, and selective TRPM8 receptor agonist

Inhibitor of gene products associated with cell survival, proliferation, invasion, and angiogenesis, targeting NF-κB pathway, showing antiproliferative activity and unique mode of action

Novel photoisomerizable potent and selective M1 ligand, mimicing the tricyclic chemical structure and display reversibly controlled activity, showing stronger inhibition upon illumination both in vitro and in cardiac atria ex vivo

Novel modulator of PI3K and NF-κB activities, blocking migration and production of inflammatory mediators

Novel substrate-competive c-Src inhibitor

Novel G9a (EHMT2) inhibitor, binding tightly inside the active site cavity of G9a, inhibiting the activity of G9a in both enzyme and cell based assays with much lesser toxicity than BIX-0129

Dual inhibitor of angiogenesis and lysophosphatidic acid acyltransferase

Novel potent dual inhibitor of ALK and c-Met

Novel cell permeable degrader of BRD4