Novel selective inhibitor of CDK7

Potent thromboxane receptor antagonist

Antimalarial agent, displaying blood schizonticidal activity against P.berghei

Novel selective bacterial dihydrofolate inhibitor, antibiotic, actively against Gram positive organisms

Novel potent and selective inhibitor of choline kinase alpha (CHKA)

Novel highly selective, substrate-competitive SIRT2 inhibitor, displaying a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line

Novel inhibitor of heat shock protein 90 (Hsp90), demonstrating anticancer activity against colorectal, osteosarcoma and cervical cancer cell lines

DNA topoisomerase II inhibitor

Potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers

Novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist

Novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist

Novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist

M1 and M2 Antagonist

Novel highly potent substrate-selective inhibitor of insulin-degrading enzyme (IDE), blocking insulin binding while allowing glucagon cleavage, even at saturating inhibitor concentrations

Novel highly potent substrate-selective inhibitor of insulin-degrading enzyme (IDE), blocking insulin binding while allowing glucagon cleavage, even at saturating inhibitor concentrations

Novel isocitrate dehydrogenase 2 (IDH2) mutants inhibitor for the treatment of cancer

Novel mutant-selective Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor

The first inhibitor targeting both IDO1/2 that has excellent in vitro inhibitory activity (IDO1 IC50 = 28 nM and IDO2 IC50 = 144 nM)

Selective ER modulator (SERM)

Novel bactericidal agent against M. tuberculosis under acidic conditions, being effective at sterilizing cultures in a concentration-dependent fashion at the highest concentrations

Novel concentration dependent bactericidal agent against M. tuberculosis, being markedly more efficient at killing M. tuberculosis under acidic conditions

Innate Defence Regulator Peptide, Enhancing Monocyte Migration and Adhesion on Fibronectin