Natural antioxidant and anti-cancer agent, blocking the MAPK/NF-κB and activating Nrf2/HO-1

Novel anticancer agent, inhibiting lung cancer cell proliferation via a PKCa and ERK1/2 dependent mechanism

Natural antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3ß

Novel analogue of combretastatin A-4, enhancing connexin43 expression

Novel potent and selective inhibitor of fat mass obesity-associated protein (FTO), being selectively over alkylation repair homologue 5 (ALKBH5), another DNA/RNA demethylase

Novel potent and selective inhibitor of human DNA polymerase kappa (hpol κ)

Selective kynurenine-3-hydroxylase inhibitor

Antibiotic enhancer against resistant Gram-negative bacteria

Antibiotic enhancer against resistant Gram-negative bacteria

Antibiotic enhancer against resistant Gram-negative bacteria

Novel antagonist of IAP (inhibitor of apoptosis protein)

Novel inhibitor of the cluster of differentiation 14 innate immunity pathway

Novel activator of LFA-1-ICAM-1 binding

First-in-class triple-acting PIM/PI3K/mTOR inhibitor, demonstrating single-agent, anti-tumour efficacy in suppression of pAKT, pmTOR and pBAD in the SKBR-3, BT-474 and HCC-1954 HER2+/PIK3CA-mutated cell lines

Novel Aurora kinase inhibitor

Novel Aurora kinase inhibitor, revealing mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Novel fluorescent irreversible inhibitor of Bruton's tyrosine kinase (BTK)

Novel HDAC6-selective inhibitor

MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis

Neuronal Kv7 potassium channel activator

Inhibitor of voltage-gated K(+) (Kv) channels Kv1.3 and Kv1.5

Novel inhibitor of CALP, exhibiting affinity of 22.6 ± 8.0 μM for CALP and no interaction with the NHERF PDZ domains